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PPP4R3B protein phosphatase 4 regulatory subunit 3B [ Homo sapiens (human) ]

Gene ID: 57223, updated on 15-Jun-2019

Summary

Official Symbol
PPP4R3Bprovided by HGNC
Official Full Name
protein phosphatase 4 regulatory subunit 3Bprovided by HGNC
Primary source
HGNC:HGNC:29267
See related
Ensembl:ENSG00000275052 MIM:610352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSY2; smk1; FLFL2; SMEK2; PP4R3B
Expression
Ubiquitous expression in thyroid (RPKM 19.2), lymph node (RPKM 17.8) and 25 other tissues See more
Orthologs

Genomic context

See PPP4R3B in Genome Data Viewer
Location:
2p16.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (55547292..55618132, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (55774428..55844860, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 634, pseudogene Neighboring gene cilia and flagella associated protein 36 Neighboring gene uncharacterized LOC107985885 Neighboring gene polyribonucleotide nucleotidyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
NHGRI GWA Catalog

Pathways from BioSystems

  • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
    Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon signaling pathway, conserved biosystem (from KEGG)
    Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31474, FLJ41002, KIAA1387

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
protein phosphatase 4 complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 3B
Names
SMEK homolog 2, suppressor of mek1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122964.3NP_001116436.3  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC015982, KF510821
    Consensus CDS
    CCDS46289.1
    Related
    ENSP00000483228.1, ENST00000616407.2
  2. NM_001282850.2NP_001269779.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 3

    See identical proteins and their annotated locations for NP_001269779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC015982, BC006215, BE535214, DB261776
    Consensus CDS
    CCDS62913.1
    UniProtKB/Swiss-Prot
    Q5MIZ7
    Related
    ENSP00000484116.1, ENST00000616288.4
    Conserved Domains (3) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:645682
    IGF2_C; Insulin-like growth factor II E-peptide
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  3. NM_020463.4NP_065196.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 2

    See identical proteins and their annotated locations for NP_065196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (2) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC015982, BC060855, BE535214, DB261776
    Consensus CDS
    CCDS1855.1
    UniProtKB/Swiss-Prot
    Q5MIZ7
    Related
    ENSP00000478677.1, ENST00000611717.4
    Conserved Domains (3) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:592629
    IGF2_C; Insulin-like growth factor II E-peptide
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    55547292..55618132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453014.1XP_024308782.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1

    Conserved Domains (3) summary
    pfam08365
    Location:677714
    IGF2_C; Insulin-like growth factor II E-peptide
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  2. XM_017004536.2XP_016860025.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X12

  3. XM_017004535.2XP_016860024.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X11

  4. XM_017004534.2XP_016860023.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X10

  5. XM_017004533.2XP_016860022.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X9

  6. XM_017004532.2XP_016860021.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X8

  7. XM_005264447.3XP_005264504.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X7

    Conserved Domains (3) summary
    pfam04802
    Location:98151
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:469506
    IGF2_C; Insulin-like growth factor II E-peptide
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  8. XM_005264445.3XP_005264502.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X5

    Conserved Domains (2) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  9. XM_017004537.2XP_016860026.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X13

    Conserved Domains (2) summary
    pfam04802
    Location:354
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:372409
    IGF2_C; Insulin-like growth factor II E-peptide
  10. XM_017004540.2XP_016860029.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X15

  11. XM_017004538.2XP_016860027.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X13

    Conserved Domains (2) summary
    pfam04802
    Location:354
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:372409
    IGF2_C; Insulin-like growth factor II E-peptide
  12. XM_017004539.2XP_016860028.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X14

  13. XM_017004531.2XP_016860020.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X3

    Conserved Domains (2) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  14. XM_005264444.3XP_005264501.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X4

    Conserved Domains (3) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:624661
    IGF2_C; Insulin-like growth factor II E-peptide
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  15. XM_005264442.3XP_005264499.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X2

    Conserved Domains (2) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  16. XM_005264446.3XP_005264503.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X6

    Conserved Domains (2) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_001738855.2 RNA Sequence

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