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PPP4R3B protein phosphatase 4 regulatory subunit 3B [ Homo sapiens (human) ]

Gene ID: 57223, updated on 5-Aug-2022

Summary

Official Symbol
PPP4R3Bprovided by HGNC
Official Full Name
protein phosphatase 4 regulatory subunit 3Bprovided by HGNC
Primary source
HGNC:HGNC:29267
See related
Ensembl:ENSG00000275052 MIM:610352; AllianceGenome:HGNC:29267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSY2; smk1; FLFL2; SMEK2; PP4R3B
Summary
Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in centrosome and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 19.2), lymph node (RPKM 17.8) and 25 other tissues See more
Orthologs
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Genomic context

See PPP4R3B in Genome Data Viewer
Location:
2p16.1
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (55547292..55617622, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (55544479..55614812, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (55774428..55844757, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 634, pseudogene Neighboring gene cilia and flagella associated protein 36 Neighboring gene small nucleolar RNA SNORA12 Neighboring gene polyribonucleotide nucleotidyltransferase 1 Neighboring gene uncharacterized LOC107985811

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31474, FLJ41002, KIAA1387

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of protein phosphatase 4 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein phosphatase 4 complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 3B
Names
SMEK homolog 2, suppressor of mek1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122964.3NP_001116436.3  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC015982, KF510821
    Consensus CDS
    CCDS46289.1
    UniProtKB/Swiss-Prot
    Q9P2G0
    Related
    ENSP00000483228.1, ENST00000616407.2
  2. NM_001282850.2NP_001269779.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 3

    See identical proteins and their annotated locations for NP_001269779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC015982, BC006215, BE535214, DB261776
    Consensus CDS
    CCDS62913.1
    UniProtKB/Swiss-Prot
    Q5MIZ7
    Related
    ENSP00000484116.1, ENST00000616288.4
    Conserved Domains (3) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:645682
    IGF2_C; Insulin-like growth factor II E-peptide
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  3. NM_020463.4NP_065196.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 2

    See identical proteins and their annotated locations for NP_065196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (2) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC015982, BC060855, BE535214, DB261776
    Consensus CDS
    CCDS1855.1
    UniProtKB/Swiss-Prot
    Q5MIZ7
    Related
    ENSP00000478677.1, ENST00000611717.4
    Conserved Domains (3) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:592629
    IGF2_C; Insulin-like growth factor II E-peptide
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    55547292..55617622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004536.3XP_016860025.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X14

  2. XM_017004535.3XP_016860024.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X13

    Conserved Domains (1) summary
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  3. XM_017004534.3XP_016860023.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X10

  4. XM_017004533.3XP_016860022.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X9

  5. XM_047445153.1XP_047301109.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X12

  6. XM_047445152.1XP_047301108.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X11

  7. XM_017004532.3XP_016860021.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X8

  8. XM_005264447.4XP_005264504.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X7

    Conserved Domains (3) summary
    pfam04802
    Location:98151
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:469506
    IGF2_C; Insulin-like growth factor II E-peptide
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  9. XM_005264446.4XP_005264503.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X5

    Conserved Domains (2) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  10. XM_017004531.3XP_016860020.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X2

    Conserved Domains (2) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  11. XM_005264445.4XP_005264502.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X4

    Conserved Domains (2) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  12. XM_005264444.4XP_005264501.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X3

    Conserved Domains (3) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    pfam08365
    Location:624661
    IGF2_C; Insulin-like growth factor II E-peptide
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  13. XM_005264442.4XP_005264499.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1

    Conserved Domains (2) summary
    pfam04802
    Location:168359
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:765
    PH-like; Pleckstrin homology-like domain
  14. XM_047445155.1XP_047301111.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X16

  15. XM_047445154.1XP_047301110.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X15

  16. XM_047445151.1XP_047301107.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    55544479..55614812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)