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SLC45A4 solute carrier family 45 member 4 [ Homo sapiens (human) ]

Gene ID: 57210, updated on 1-Jun-2020

Summary

Official Symbol
SLC45A4provided by HGNC
Official Full Name
solute carrier family 45 member 4provided by HGNC
Primary source
HGNC:HGNC:29196
See related
Ensembl:ENSG00000022567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 5.0), stomach (RPKM 3.0) and 24 other tissues See more
Orthologs

Genomic context

See SLC45A4 in Genome Data Viewer
Location:
8q24.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (141207166..141308321, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142217273..142310241, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927963 Neighboring gene DENN domain containing 3 Neighboring gene uncharacterized LOC105375785 Neighboring gene uncharacterized LOC105375787 Neighboring gene long intergenic non-protein coding RNA 1300 Neighboring gene G protein-coupled receptor 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sucrose:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sucrose:proton symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
sucrose transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
solute carrier family 45 member 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080431.2NP_001073900.1  solute carrier family 45 member 4 isoform 2

    See identical proteins and their annotated locations for NP_001073900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon compared to variant 1. This variant (2) also uses an alternate splice site in the 3' coding region which results in a frame shift. The encoded isoform (2) is shorter and has a distinct N- and C- termini compared to isoform 1.
    Source sequence(s)
    AC011676, AI769055, AK128212
    Consensus CDS
    CCDS34948.1
    UniProtKB/Swiss-Prot
    Q5BKX6
    Related
    ENSP00000024061.3, ENST00000024061.7
    Conserved Domains (1) summary
    cd06174
    Location:24200
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. NM_001286646.2NP_001273575.1  solute carrier family 45 member 4 isoform 1

    See identical proteins and their annotated locations for NP_001273575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC011676
    Consensus CDS
    CCDS75795.1
    UniProtKB/Swiss-Prot
    Q5BKX6
    UniProtKB/TrEMBL
    B2RXG1, E7EV90
    Conserved Domains (1) summary
    cd06174
    Location:52251
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. NM_001286648.1NP_001273577.1  solute carrier family 45 member 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon compared to variant 1. This variant (2) also uses an alternate splice site in the 3' coding region which results in a frame shift. The encoded isoform (3) is shorter and has a distinct N- and C- termini compared to isoform 1
    Source sequence(s)
    AK128212, BC090891
    Consensus CDS
    CCDS69550.1
    UniProtKB/Swiss-Prot
    Q5BKX6
    Related
    ENSP00000429059.1, ENST00000519067.5
    Conserved Domains (1) summary
    cd06174
    Location:24200
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    141207166..141308321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517179.2XP_011515481.1  solute carrier family 45 member 4 isoform X8

    Conserved Domains (1) summary
    cd06174
    Location:325521
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. XM_011517176.2XP_011515478.1  solute carrier family 45 member 4 isoform X5

    Conserved Domains (1) summary
    cd06174
    Location:455651
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. XM_017013649.1XP_016869138.1  solute carrier family 45 member 4 isoform X1

    UniProtKB/TrEMBL
    E7EV90
    Related
    ENSP00000428137.1, ENST00000517878.5
    Conserved Domains (1) summary
    cd06174
    Location:52251
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  4. XM_011517170.2XP_011515472.1  solute carrier family 45 member 4 isoform X1

    See identical proteins and their annotated locations for XP_011515472.1

    UniProtKB/TrEMBL
    E7EV90
    Conserved Domains (1) summary
    cd06174
    Location:52251
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  5. XM_011517171.2XP_011515473.1  solute carrier family 45 member 4 isoform X1

    See identical proteins and their annotated locations for XP_011515473.1

    UniProtKB/TrEMBL
    E7EV90
    Conserved Domains (1) summary
    cd06174
    Location:52251
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  6. XM_017013650.2XP_016869139.1  solute carrier family 45 member 4 isoform X4

    Conserved Domains (1) summary
    cd06174
    Location:16188
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  7. XM_017013648.1XP_016869137.1  solute carrier family 45 member 4 isoform X1

    UniProtKB/TrEMBL
    E7EV90
    Conserved Domains (1) summary
    cd06174
    Location:52251
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  8. XM_011517172.2XP_011515474.1  solute carrier family 45 member 4 isoform X1

    See identical proteins and their annotated locations for XP_011515474.1

    UniProtKB/TrEMBL
    E7EV90
    Conserved Domains (1) summary
    cd06174
    Location:52251
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  9. XM_011517178.2XP_011515480.1  solute carrier family 45 member 4 isoform X7

    Conserved Domains (1) summary
    cd06174
    Location:4180
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  10. XM_011517177.2XP_011515479.1  solute carrier family 45 member 4 isoform X6

    Conserved Domains (1) summary
    cd06174
    Location:7182
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  11. XM_011517174.2XP_011515476.1  solute carrier family 45 member 4 isoform X3

    Conserved Domains (1) summary
    cd06174
    Location:24200
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  12. XM_011517173.2XP_011515475.1  solute carrier family 45 member 4 isoform X2

    Conserved Domains (1) summary
    cd06174
    Location:52251
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
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