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ATP10D ATPase phospholipid transporting 10D (putative) [ Homo sapiens (human) ]

Gene ID: 57205, updated on 12-Oct-2019

Summary

Official Symbol
ATP10Dprovided by HGNC
Official Full Name
ATPase phospholipid transporting 10D (putative)provided by HGNC
Primary source
HGNC:HGNC:13549
See related
Ensembl:ENSG00000145246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPVD
Expression
Ubiquitous expression in placenta (RPKM 7.9), skin (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See ATP10D in Genome Data Viewer
Location:
4p12
Exon count:
25
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (47485261..47593486)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (47487296..47595503)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986277 Neighboring gene COMM domain containing 8 Neighboring gene ribosomal protein L21 pseudogene 52 Neighboring gene uncharacterized LOC105374444 Neighboring gene corin, serine peptidase Neighboring gene uncharacterized LOC105374443

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic determinants of circulating sphingolipid concentrations in European populations.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1487

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
magnesium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cation transport NAS
Non-traceable Author Statement
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid translocation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable phospholipid-transporting ATPase VD
Names
ATPase, class V, type 10D
P4-ATPase flippase complex alpha subunit ATP10D
type IV aminophospholipid transporting ATPase
NP_065186.3
XP_005248176.1
XP_005248177.1
XP_011512024.1
XP_016863961.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020453.4NP_065186.3  probable phospholipid-transporting ATPase VD

    See identical proteins and their annotated locations for NP_065186.3

    Status: VALIDATED

    Source sequence(s)
    AC107398, AJ441078, BC131535
    Consensus CDS
    CCDS3476.1
    UniProtKB/Swiss-Prot
    Q9P241
    Related
    ENSP00000273859.3, ENST00000273859.8
    Conserved Domains (6) summary
    TIGR01652
    Location:711327
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:128216
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:727807
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:71122
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:10821327
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:10511082
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    47485261..47593486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248119.4XP_005248176.1  probable phospholipid-transporting ATPase VD isoform X1

    Conserved Domains (6) summary
    TIGR01652
    Location:711312
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:128216
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:712792
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:71122
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:10671312
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:10361067
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. XM_011513722.2XP_011512024.1  probable phospholipid-transporting ATPase VD isoform X3

    Conserved Domains (5) summary
    TIGR01652
    Location:711262
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:662742
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:7197
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:10171262
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:9861017
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  3. XM_005248120.4XP_005248177.1  probable phospholipid-transporting ATPase VD isoform X2

    Conserved Domains (6) summary
    TIGR01652
    Location:711300
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:128216
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:727807
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:71122
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:10821300
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:10511082
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  4. XM_017008472.1XP_016863961.1  probable phospholipid-transporting ATPase VD isoform X4

    Conserved Domains (5) summary
    COG0474
    Location:225859
    MgtA; Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism]
    TIGR01484
    Location:395581
    HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
    pfam13246
    Location:235315
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:590835
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:559590
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. XR_001741295.1 RNA Sequence

  2. XR_925154.2 RNA Sequence

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