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ATP8B2 ATPase phospholipid transporting 8B2 [ Homo sapiens (human) ]

Gene ID: 57198, updated on 1-Jun-2020

Summary

Official Symbol
ATP8B2provided by HGNC
Official Full Name
ATPase phospholipid transporting 8B2provided by HGNC
Primary source
HGNC:HGNC:13534
See related
Ensembl:ENSG00000143515 MIM:605867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPID
Summary
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 16.7), endometrium (RPKM 13.3) and 23 other tissues See more
Orthologs

Genomic context

See ATP8B2 in Genome Data Viewer
Location:
1q21.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (154325525..154351304)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154298036..154323780)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 121, pseudogene Neighboring gene aquaporin 10 Neighboring gene RNA, U7 small nuclear 57 pseudogene Neighboring gene mitochondrial ribosomal protein S33 pseudogene 1 Neighboring gene ribosomal protein SA pseudogene 17 Neighboring gene IL6R antisense RNA 1 Neighboring gene interleukin 6 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1137, DKFZp434M0219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phospholipid-transporting ATPase ID
Names
36/8-9 fusion protein with epitope for anti-lectin antibody
ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATPase, class I, type 8B, member 2
P4-ATPase flippase complex alpha subunit ATP8B2
probable phospholipid-transporting ATPase ID
NP_001005855.1
NP_001354863.1
NP_001357525.1
NP_001357526.1
NP_001358938.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005855.2NP_001005855.1  phospholipid-transporting ATPase ID isoform b

    See identical proteins and their annotated locations for NP_001005855.1

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Consensus CDS
    CCDS41405.1
    UniProtKB/Swiss-Prot
    P98198
    Related
    ENSP00000357472.3, ENST00000368487.7
    Conserved Domains (1) summary
    pfam16209
    Location:1880
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
  2. NM_001367934.1NP_001354863.1  phospholipid-transporting ATPase ID isoform c

    Status: REVIEWED

    Source sequence(s)
    AL162591
  3. NM_001370596.1NP_001357525.1  phospholipid-transporting ATPase ID isoform d

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Conserved Domains (1) summary
    cd02073
    Location:31973
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  4. NM_001370597.1NP_001357526.1  phospholipid-transporting ATPase ID isoform e

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Conserved Domains (1) summary
    cd02073
    Location:31972
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  5. NM_001372009.1NP_001358938.1  phospholipid-transporting ATPase ID isoform e

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Consensus CDS
    CCDS1066.1
    Related
    ENSP00000357475.4, ENST00000368489.5
    Conserved Domains (1) summary
    cd02073
    Location:31972
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    154325525..154351304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020452.4: Suppressed sequence

    Description
    NM_020452.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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