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DENND11 DENN domain containing 11 [ Homo sapiens (human) ]

Gene ID: 57189, updated on 11-Jun-2021

Summary

Official Symbol
DENND11provided by HGNC
Official Full Name
DENN domain containing 11provided by HGNC
Primary source
HGNC:HGNC:29472
See related
Ensembl:ENSG00000257093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCHN; PRO2561; KIAA1147
Expression
Ubiquitous expression in brain (RPKM 17.1), thyroid (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

See DENND11 in Genome Data Viewer
Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (141652381..141702188, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141356528..141401966, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane protein 178B Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 pseudogene 2 Neighboring gene AGK divergent transcript Neighboring gene acylglycerol kinase Neighboring gene WEE2 antisense RNA 1 Neighboring gene RNA, U1 small nuclear 82, pseudogene Neighboring gene WEE2 oocyte meiosis inhibiting kinase Neighboring gene single stranded DNA binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DENN domain-containing protein 11
Names
predicted protein of HQ2561
protein LCHN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080392.2NP_001073861.1  DENN domain-containing protein 11

    See identical proteins and their annotated locations for NP_001073861.1

    Status: VALIDATED

    Source sequence(s)
    AC004918
    Consensus CDS
    CCDS47726.1
    UniProtKB/Swiss-Prot
    A4D1U4
    Related
    ENSP00000445768.1, ENST00000536163.6
    Conserved Domains (1) summary
    pfam09804
    Location:80346
    DUF2347; Uncharacterized conserved protein (DUF2347)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    141652381..141702188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446843.1XP_024302611.1  DENN domain-containing protein 11 isoform X1

    Conserved Domains (1) summary
    pfam09804
    Location:80346
    DUF2347; Uncharacterized conserved protein (DUF2347)

RNA

  1. XR_001744838.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315922.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    23320..68761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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