Format

Send to:

Choose Destination

THOC2 THO complex 2 [ Homo sapiens (human) ]

Gene ID: 57187, updated on 25-Nov-2021

Summary

Official Symbol
THOC2provided by HGNC
Official Full Name
THO complex 2provided by HGNC
Primary source
HGNC:HGNC:19073
See related
Ensembl:ENSG00000125676 MIM:300395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THO2; MRX12; MRX35; CXorf3; XLID12; hTREX120; dJ506G2.1
Summary
The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in lymph node (RPKM 8.1), thyroid (RPKM 7.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See THOC2 in Genome Data Viewer
Location:
Xq25
Exon count:
41
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (123600563..123733054, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (122734420..122866902, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene tubulin beta 4A class IVa pseudogene 1 Neighboring gene FER tyrosine kinase pseudogene 1 Neighboring gene RNA, U7 small nuclear 69 pseudogene Neighboring gene mediator of cell motility 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of THO complex 2 (THOC2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify THO complex 2 protein (THOC2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify THO complex 2 protein (THOC2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify THO complex 2 protein (THOC2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify THO complex 2 protein (THOC2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in generation of neurons IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in poly(A)+ mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of THO complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
THO complex subunit 2
Names
mental retardation, X-linked 12
mental retardation, X-linked 35

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021468.1 RefSeqGene

    Range
    5003..137485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001081550.2NP_001075019.1  THO complex subunit 2

    See identical proteins and their annotated locations for NP_001075019.1

    Status: REVIEWED

    Source sequence(s)
    AF441770, AW206982, BC054050, DA504931
    Consensus CDS
    CCDS43988.1
    UniProtKB/Swiss-Prot
    Q8NI27
    Related
    ENSP00000245838.8, ENST00000245838.13
    Conserved Domains (5) summary
    PTZ00121
    Location:12911593
    PTZ00121; MAEBL; Provisional
    TIGR01642
    Location:14481556
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam11262
    Location:8741173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:11566
    THOC2_N; THO complex subunit 2 N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    123600563..123733054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029679.1XP_016885168.1  THO complex subunit 2 isoform X6

  2. XM_017029675.1XP_016885164.1  THO complex subunit 2 isoform X5

  3. XM_017029672.1XP_016885161.1  THO complex subunit 2 isoform X4

  4. XM_017029667.1XP_016885156.1  THO complex subunit 2 isoform X3

  5. XM_017029662.1XP_016885151.1  THO complex subunit 2 isoform X1

  6. XM_017029664.1XP_016885153.1  THO complex subunit 2 isoform X2

  7. XM_017029676.1XP_016885165.1  THO complex subunit 2 isoform X5

  8. XM_017029668.1XP_016885157.1  THO complex subunit 2 isoform X3

  9. XM_017029665.1XP_016885154.1  THO complex subunit 2 isoform X2

  10. XM_017029663.1XP_016885152.1  THO complex subunit 2 isoform X1

RNA

  1. XR_002958797.1 RNA Sequence

  2. XR_002958796.1 RNA Sequence

  3. XR_002958793.1 RNA Sequence

  4. XR_002958795.1 RNA Sequence

  5. XR_002958792.1 RNA Sequence

  6. XR_002958789.1 RNA Sequence

  7. XR_002958786.1 RNA Sequence

  8. XR_002958794.1 RNA Sequence

  9. XR_002958790.1 RNA Sequence

  10. XR_002958788.1 RNA Sequence

  11. XR_002958791.1 RNA Sequence

  12. XR_002958787.1 RNA Sequence

  13. XR_002958785.1 RNA Sequence

  14. XR_001755714.1 RNA Sequence

  15. XR_001755715.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020449.2: Suppressed sequence

    Description
    NM_020449.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Support Center