Format

Send to:

Choose Destination

ACTR3B actin related protein 3B [ Homo sapiens (human) ]

Gene ID: 57180, updated on 6-May-2021

Summary

Official Symbol
ACTR3Bprovided by HGNC
Official Full Name
actin related protein 3Bprovided by HGNC
Primary source
HGNC:HGNC:17256
See related
Ensembl:ENSG00000133627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP11; ARP3BETA
Summary
This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Broad expression in brain (RPKM 3.7), testis (RPKM 1.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ACTR3B in Genome Data Viewer
Location:
7q36.1-q36.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (152759752..153070979)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (152456837..152552463)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 845, pseudogene Neighboring gene small ubiquitin-related modifier 2 pseudogene Neighboring gene uncharacterized LOC102723686 Neighboring gene Sharpr-MPRA regulatory region 3392

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686O24114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
actin-related protein 3B
Names
ARP3 actin related protein 3 homolog B
ARP3-beta
actin-like protein 3B
actin-related protein 3-beta
actin-related protein ARP4
actin-related protein Arp11

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040135.3NP_001035225.1  actin-related protein 3B isoform 2

    See identical proteins and their annotated locations for NP_001035225.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AA559050, AB209174, AK294292, BC015207, DN601600
    Consensus CDS
    CCDS34782.1
    UniProtKB/Swiss-Prot
    Q9P1U1
    UniProtKB/TrEMBL
    Q59GD5
    Related
    ENSP00000367007.3, ENST00000377776.7
    Conserved Domains (1) summary
    cl25542
    Location:2347
    Actin; Actin
  2. NM_001350940.2NP_001337869.1  actin-related protein 3B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 4, 5, and 6, encodes isoform 3.
    Source sequence(s)
    AC072057, AC092180
    Consensus CDS
    CCDS87568.1
    Related
    ENSP00000380452.2, ENST00000397282.2
    Conserved Domains (1) summary
    PTZ00280
    Location:1329
    PTZ00280; Actin-related protein 3; Provisional
  3. NM_001350941.2NP_001337870.1  actin-related protein 3B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform 3.
    Source sequence(s)
    AC072057, AC092180
    Consensus CDS
    CCDS87568.1
    Conserved Domains (1) summary
    PTZ00280
    Location:1329
    PTZ00280; Actin-related protein 3; Provisional
  4. NM_001350942.2NP_001337871.1  actin-related protein 3B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform 3.
    Source sequence(s)
    AC072057, AC092180
    Consensus CDS
    CCDS87568.1
    Conserved Domains (1) summary
    PTZ00280
    Location:1329
    PTZ00280; Actin-related protein 3; Provisional
  5. NM_001350943.2NP_001337872.1  actin-related protein 3B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 3, 4, and 5, encodes isoform 3.
    Source sequence(s)
    AC072057, AC092180
    Consensus CDS
    CCDS87568.1
    Conserved Domains (1) summary
    PTZ00280
    Location:1329
    PTZ00280; Actin-related protein 3; Provisional
  6. NM_001350944.2NP_001337873.1  actin-related protein 3B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
    Conserved Domains (1) summary
    cl25542
    Location:2375
    Actin
  7. NM_001350945.2NP_001337874.1  actin-related protein 3B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
    Conserved Domains (1) summary
    PTZ00280
    Location:1288
    PTZ00280; Actin-related protein 3; Provisional
  8. NM_001350946.2NP_001337875.1  actin-related protein 3B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
    Conserved Domains (1) summary
    cl25542
    Location:1259
    Actin; Actin
  9. NM_020445.6NP_065178.1  actin-related protein 3B isoform 1

    See identical proteins and their annotated locations for NP_065178.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA559050, AB209174, AK315534, DN601600
    Consensus CDS
    CCDS5934.1
    UniProtKB/Swiss-Prot
    Q9P1U1
    UniProtKB/TrEMBL
    Q59GD5
    Related
    ENSP00000256001.8, ENST00000256001.13
    Conserved Domains (1) summary
    PTZ00280
    Location:2417
    PTZ00280; Actin-related protein 3; Provisional

RNA

  1. NR_146946.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
  2. NR_146947.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
  3. NR_146948.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
  4. NR_146949.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
  5. NR_146950.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
  6. NR_146951.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    152759752..153070979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012460.1XP_016867949.1  actin-related protein 3B isoform X2

  2. XM_006716065.2XP_006716128.1  actin-related protein 3B isoform X1

    Conserved Domains (1) summary
    COG5277
    Location:1331
    COG5277; Actin-related protein [Cytoskeleton]
  3. XM_011516425.2XP_011514727.1  actin-related protein 3B isoform X4

    Conserved Domains (1) summary
    COG5277
    Location:1317
    COG5277; Actin-related protein [Cytoskeleton]
  4. XM_011516426.2XP_011514728.1  actin-related protein 3B isoform X5

    Conserved Domains (1) summary
    COG5277
    Location:1321
    COG5277; Actin-related protein [Cytoskeleton]
  5. XM_017012461.1XP_016867950.1  actin-related protein 3B isoform X8

  6. XM_006716067.4XP_006716130.1  actin-related protein 3B isoform X6

    Conserved Domains (1) summary
    COG5277
    Location:1319
    COG5277; Actin-related protein [Cytoskeleton]
  7. XM_011516427.1XP_011514729.1  actin-related protein 3B isoform X7

    Conserved Domains (1) summary
    COG5277
    Location:1317
    COG5277; Actin-related protein [Cytoskeleton]
  8. XM_006716066.1XP_006716129.1  actin-related protein 3B isoform X3

    Conserved Domains (1) summary
    COG5277
    Location:1320
    COG5277; Actin-related protein [Cytoskeleton]
  9. XM_017012463.1XP_016867952.1  actin-related protein 3B isoform X9

    Conserved Domains (1) summary
    PTZ00280
    Location:1288
    PTZ00280; Actin-related protein 3; Provisional
  10. XM_017012465.1XP_016867954.1  actin-related protein 3B isoform X10

Support Center