U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZMIZ1 zinc finger MIZ-type containing 1 [ Homo sapiens (human) ]

Gene ID: 57178, updated on 12-Aug-2022

Summary

Official Symbol
ZMIZ1provided by HGNC
Official Full Name
zinc finger MIZ-type containing 1provided by HGNC
Primary source
HGNC:HGNC:16493
See related
Ensembl:ENSG00000108175 MIM:607159; AllianceGenome:HGNC:16493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIZ; RAI17; ZIMP10; NEDDFSA; TRAFIP10
Summary
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in ovary (RPKM 21.7), spleen (RPKM 21.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZMIZ1 in Genome Data Viewer
Location:
10q22.3
Exon count:
27
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (79068966..79316519)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (79938246..80185863)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (80828723..81076276)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378379 Neighboring gene ZMIZ1 antisense RNA 1 Neighboring gene uncharacterized LOC112268062 Neighboring gene HNF1 motif-containing MPRA enhancer 157 Neighboring gene Sharpr-MPRA regulatory region 11789 Neighboring gene Sharpr-MPRA regulatory region 4581 Neighboring gene HNF1 motif-containing MPRA enhancer 4 Neighboring gene Sharpr-MPRA regulatory region 270 Neighboring gene VISTA enhancer hs1767 Neighboring gene Sharpr-MPRA regulatory region 8427 Neighboring gene Sharpr-MPRA regulatory region 1120 Neighboring gene peptidylprolyl isomerase F Neighboring gene zinc finger CCHC-type containing 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies
MedGen: C5231448 OMIM: 618659 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide scan for breast cancer risk haplotypes among African American women.
EBI GWAS Catalog
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
EBI GWAS Catalog
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
EBI GWAS Catalog
Common variants at five new loci associated with early-onset inflammatory bowel disease.
EBI GWAS Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
EBI GWAS Catalog
Genome-wide association study identifies five new breast cancer susceptibility loci.
EBI GWAS Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00092, FLJ13541, KIAA1224

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular senescence IEA
Inferred from Electronic Annotation
more info
 
involved_in developmental growth IEA
Inferred from Electronic Annotation
more info
 
involved_in heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nucleic acid-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyramidal neuron migration to cerebral cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in vitellogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger MIZ domain-containing protein 1
Names
retinoic acid induced 17
zinc finger-containing, Miz1, PIAS-like protein on chromosome 10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028289.1 RefSeqGene

    Range
    4932..252485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020338.4NP_065071.1  zinc finger MIZ domain-containing protein 1

    See identical proteins and their annotated locations for NP_065071.1

    Status: REVIEWED

    Source sequence(s)
    AB033050, AL356753, AL358782, AL391665, AY235683, BC007288
    Consensus CDS
    CCDS7357.1
    UniProtKB/Swiss-Prot
    Q7Z7E6, Q9ULJ6
    UniProtKB/TrEMBL
    A0JLS3
    Related
    ENSP00000334474.5, ENST00000334512.10
    Conserved Domains (3) summary
    pfam09606
    Location:184557
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:739786
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    79068966..79316519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425538.1XP_047281494.1  zinc finger MIZ domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A024QZN6
  2. XM_047425539.1XP_047281495.1  zinc finger MIZ domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q7Z7E6
  3. XM_005269988.4XP_005270045.1  zinc finger MIZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005270045.1

    UniProtKB/TrEMBL
    A0A024QZN6
    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  4. XM_006717925.4XP_006717988.1  zinc finger MIZ domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  5. XM_047425542.1XP_047281498.1  zinc finger MIZ domain-containing protein 1 isoform X4

  6. XM_006717923.4XP_006717986.1  zinc finger MIZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006717986.1

    UniProtKB/TrEMBL
    A0A024QZN6
    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  7. XM_047425541.1XP_047281497.1  zinc finger MIZ domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q7Z7E6
  8. XM_047425543.1XP_047281499.1  zinc finger MIZ domain-containing protein 1 isoform X4

  9. XM_006717924.4XP_006717987.1  zinc finger MIZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006717987.1

    UniProtKB/TrEMBL
    A0A024QZN6
    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  10. XM_047425540.1XP_047281496.1  zinc finger MIZ domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q7Z7E6
  11. XM_011539979.2XP_011538281.1  zinc finger MIZ domain-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011538281.1

    Conserved Domains (2) summary
    pfam09606
    Location:60439
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:621668
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    79938246..80185863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)