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ZMIZ1 zinc finger MIZ-type containing 1 [ Homo sapiens (human) ]

Gene ID: 57178, updated on 4-Jul-2021

Summary

Official Symbol
ZMIZ1provided by HGNC
Official Full Name
zinc finger MIZ-type containing 1provided by HGNC
Primary source
HGNC:HGNC:16493
See related
Ensembl:ENSG00000108175 MIM:607159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIZ; RAI17; ZIMP10; NEDDFSA; TRAFIP10
Summary
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in ovary (RPKM 21.7), spleen (RPKM 21.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZMIZ1 in Genome Data Viewer
Location:
10q22.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (79068966..79316519)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (80828723..81076276)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378379 Neighboring gene ZMIZ1 antisense RNA 1 Neighboring gene uncharacterized LOC112268062 Neighboring gene HNF1 motif-containing MPRA enhancer 157 Neighboring gene HNF1 motif-containing MPRA enhancer 4 Neighboring gene VISTA enhancer hs1767 Neighboring gene Sharpr-MPRA regulatory region 8427 Neighboring gene uncharacterized LOC107984247 Neighboring gene peptidylprolyl isomerase F Neighboring gene zinc finger CCHC-type containing 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide scan for breast cancer risk haplotypes among African American women.
GeneReviews: Not available
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
GeneReviews: Not available
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
GeneReviews: Not available
Common variants at five new loci associated with early-onset inflammatory bowel disease.
GeneReviews: Not available
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
GeneReviews: Not available
Genome-wide association study identifies five new breast cancer susceptibility loci.
GeneReviews: Not available
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
GeneReviews: Not available
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
GeneReviews: Not available
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
GeneReviews: Not available
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
GeneReviews: Not available
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
GeneReviews: Not available
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
GeneReviews: Not available
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
GeneReviews: Not available
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available
Multiple common variants for celiac disease influencing immune gene expression.
GeneReviews: Not available
Neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies
MedGen: C5231448 OMIM: 618659 GeneReviews: Not available
not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00092, FLJ13541, KIAA1224

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell aging IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin-mediated maintenance of transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in developmental growth IEA
Inferred from Electronic Annotation
more info
 
involved_in heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nucleic acid-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyramidal neuron migration to cerebral cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in vitellogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger MIZ domain-containing protein 1
Names
retinoic acid induced 17
zinc finger-containing, Miz1, PIAS-like protein on chromosome 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028289.1 RefSeqGene

    Range
    4932..252485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020338.4NP_065071.1  zinc finger MIZ domain-containing protein 1

    See identical proteins and their annotated locations for NP_065071.1

    Status: REVIEWED

    Source sequence(s)
    AB033050, AL356753, AL358782, AL391665, AY235683, BC007288
    Consensus CDS
    CCDS7357.1
    UniProtKB/Swiss-Prot
    Q9ULJ6
    UniProtKB/TrEMBL
    A0JLS3
    Related
    ENSP00000334474.5, ENST00000334512.10
    Conserved Domains (3) summary
    pfam09606
    Location:184557
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:739786
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    79068966..79316519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269988.3XP_005270045.1  zinc finger MIZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005270045.1

    UniProtKB/TrEMBL
    A0A024QZN6
    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  2. XM_006717925.3XP_006717988.1  zinc finger MIZ domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  3. XM_006717923.3XP_006717986.1  zinc finger MIZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006717986.1

    UniProtKB/TrEMBL
    A0A024QZN6
    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  4. XM_006717924.3XP_006717987.1  zinc finger MIZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006717987.1

    UniProtKB/TrEMBL
    A0A024QZN6
    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  5. XM_005269987.5XP_005270044.1  zinc finger MIZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005270044.1

    UniProtKB/TrEMBL
    A0A024QZN6
    Conserved Domains (3) summary
    pfam09606
    Location:184563
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:745792
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    pfam18028
    Location:8100
    Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
  6. XM_011539979.1XP_011538281.1  zinc finger MIZ domain-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011538281.1

    Conserved Domains (2) summary
    pfam09606
    Location:60439
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:621668
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  7. XM_017016442.1XP_016871931.1  zinc finger MIZ domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    pfam09606
    Location:26433
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02891
    Location:614662
    zf-MIZ; MIZ/SP-RING zinc finger
  8. XM_017016443.1XP_016871932.1  zinc finger MIZ domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    pfam09606
    Location:60439
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:621668
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  9. XM_017016441.1XP_016871930.1  zinc finger MIZ domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    pfam09606
    Location:60439
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:621668
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  10. XM_011539978.2XP_011538280.1  zinc finger MIZ domain-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011538280.1

    Conserved Domains (2) summary
    pfam09606
    Location:60439
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16791
    Location:621668
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  11. XM_011539980.3XP_011538282.1  zinc finger MIZ domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    pfam09606
    Location:26433
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02891
    Location:614662
    zf-MIZ; MIZ/SP-RING zinc finger
  12. XM_017016440.2XP_016871929.1  zinc finger MIZ domain-containing protein 1 isoform X2

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