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DOLPP1 dolichyldiphosphatase 1 [ Homo sapiens (human) ]

Gene ID: 57171, updated on 24-Nov-2020

Summary

Official Symbol
DOLPP1provided by HGNC
Official Full Name
dolichyldiphosphatase 1provided by HGNC
Primary source
HGNC:HGNC:29565
See related
Ensembl:ENSG00000167130 MIM:614516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LSFR2
Summary
A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in duodenum (RPKM 12.5), small intestine (RPKM 11.5) and 25 other tissues See more
Orthologs

Genomic context

See DOLPP1 in Genome Data Viewer
Location:
9q34.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (129080988..129090438)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131843383..131852717)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nucleoporin 188 Neighboring gene SH3 domain containing GRB2 like, endophilin B2 Neighboring gene mitoguardin 2 Neighboring gene carnitine O-acetyltransferase Neighboring gene protein phosphatase 2 phosphatase activator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dolichyldiphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dolichyldiphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
dolichyldiphosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
dolichyl diphosphate biosynthetic process TAS
Traceable Author Statement
more info
 
lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dolichyldiphosphatase 1
Names
dolichyl pyrophosphate phosphatase 1
linked to Surfeit genes in Fugu rubripes 2
NP_001129389.1
NP_065171.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135917.2NP_001129389.1  dolichyldiphosphatase 1 isoform b

    See identical proteins and their annotated locations for NP_001129389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform b which is shorter compared to isoform a.
    Source sequence(s)
    BC009493, BC033686, DA590931
    Consensus CDS
    CCDS48039.1
    UniProtKB/Swiss-Prot
    Q86YN1
    Related
    ENSP00000384043.3, ENST00000406974.7
    Conserved Domains (1) summary
    cd03382
    Location:16154
    PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...
  2. NM_020438.5NP_065171.2  dolichyldiphosphatase 1 isoform a

    See identical proteins and their annotated locations for NP_065171.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC009493, BC033686, DA590931
    Consensus CDS
    CCDS6918.1
    UniProtKB/Swiss-Prot
    Q86YN1
    UniProtKB/TrEMBL
    A0A024R8B5
    Related
    ENSP00000361625.4, ENST00000372546.9
    Conserved Domains (1) summary
    cd03382
    Location:16180
    PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...

RNA

  1. NR_072983.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK290713, BC033686, BC040152, BC067858
    Related
    ENST00000327812.12

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    129080988..129090438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002956797.1 RNA Sequence

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