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ZNFX1 zinc finger NFX1-type containing 1 [ Homo sapiens (human) ]

Gene ID: 57169, updated on 21-Dec-2019

Summary

Official Symbol
ZNFX1provided by HGNC
Official Full Name
zinc finger NFX1-type containing 1provided by HGNC
Primary source
HGNC:HGNC:29271
See related
Ensembl:ENSG00000124201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lung (RPKM 11.1), spleen (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See ZNFX1 in Genome Data Viewer
Location:
20q13.13
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49245900..49278057, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47862437..47894756, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene staufen double-stranded RNA binding protein 1 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 1 Neighboring gene DEAD-box helicase 27 Neighboring gene Sharpr-MPRA regulatory region 13855 Neighboring gene small nucleolar RNA, C/D box 12C Neighboring gene ZNFX1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39275, MGC131926

Gene Ontology Provided by GOA

Process Evidence Code Pubs
chromatin silencing at centromere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing by small RNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear RNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NFX1-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021035.3NP_066363.1  NFX1-type zinc finger-containing protein 1

    See identical proteins and their annotated locations for NP_066363.1

    Status: VALIDATED

    Source sequence(s)
    AB037825, AK096594, AL049766, AU140771, DA809204
    Consensus CDS
    CCDS13417.1
    UniProtKB/Swiss-Prot
    Q9P2E3
    Related
    ENSP00000379412.1, ENST00000396105.6
    Conserved Domains (6) summary
    cd06008
    Location:14611505
    NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
    COG1112
    Location:9031254
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13086
    Location:5971038
    AAA_11; AAA domain
    pfam13087
    Location:10511234
    AAA_12; AAA domain
    pfam13245
    Location:604667
    AAA_19; Part of AAA domain
    pfam15042
    Location:14981562
    LELP1; Late cornified envelope-like proline-rich protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    49245900..49278057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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