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PELI1 pellino E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 57162, updated on 13-Mar-2020

Summary

Official Symbol
PELI1provided by HGNC
Official Full Name
pellino E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:8827
See related
Ensembl:ENSG00000197329 MIM:614797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in bone marrow (RPKM 57.0), esophagus (RPKM 14.7) and 19 other tissues See more
Orthologs

Genomic context

See PELI1 in Genome Data Viewer
Location:
2p14
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (64092652..64144421, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (64319786..64371605, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UDP-glucose pyrophosphorylase 2 Neighboring gene VPS54 subunit of GARP complex Neighboring gene long intergenic non-protein coding RNA 309 Neighboring gene uncharacterized LOC100507006

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease.
NHGRI GWA Catalog
A genome-wide association study in Koreans identifies susceptibility loci for allergic nickel dermatitis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of pellino E3 ubiquitin protein ligase 1 (PELI1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC50990, DKFZp686C18116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-ubiquitin ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 3 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K48-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to dsRNA IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
condensed nuclear chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase pellino homolog 1
Names
RING-type E3 ubiquitin transferase pellino homolog 1
pellino homolog 1
pellino-1
pellino-related intracellular-signaling molecule
protein pellino homolog 1
NP_065702.2
XP_005264494.1
XP_011531296.1
XP_011531298.1
XP_011531299.1
XP_016860009.1
XP_016860010.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020651.4NP_065702.2  E3 ubiquitin-protein ligase pellino homolog 1

    See identical proteins and their annotated locations for NP_065702.2

    Status: VALIDATED

    Source sequence(s)
    BC050019, BM992606
    Consensus CDS
    CCDS1876.1
    UniProtKB/Swiss-Prot
    Q96FA3
    UniProtKB/TrEMBL
    Q53T26
    Related
    ENSP00000351789.4, ENST00000358912.5
    Conserved Domains (1) summary
    pfam04710
    Location:10418
    Pellino

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    64092652..64144421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004521.2XP_016860010.1  E3 ubiquitin-protein ligase pellino homolog 1 isoform X2

    Conserved Domains (1) summary
    pfam04710
    Location:2352
    Pellino; Pellino
  2. XM_005264437.3XP_005264494.1  E3 ubiquitin-protein ligase pellino homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_005264494.1

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino; Pellino
  3. XM_011532997.2XP_011531299.1  E3 ubiquitin-protein ligase pellino homolog 1 isoform X4

    Conserved Domains (1) summary
    pfam04710
    Location:1239
    Pellino; Pellino
  4. XM_011532996.2XP_011531298.1  E3 ubiquitin-protein ligase pellino homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_011531298.1

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino; Pellino
  5. XM_017004520.1XP_016860009.1  E3 ubiquitin-protein ligase pellino homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96FA3
    UniProtKB/TrEMBL
    Q53T26
    Conserved Domains (1) summary
    pfam04710
    Location:10418
    Pellino
  6. XM_011532994.3XP_011531296.1  E3 ubiquitin-protein ligase pellino homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011531296.1

    UniProtKB/Swiss-Prot
    Q96FA3
    UniProtKB/TrEMBL
    Q53T26
    Conserved Domains (1) summary
    pfam04710
    Location:10418
    Pellino
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