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PELI2 pellino E3 ubiquitin protein ligase family member 2 [ Homo sapiens (human) ]

Gene ID: 57161, updated on 13-Mar-2020

Summary

Official Symbol
PELI2provided by HGNC
Official Full Name
pellino E3 ubiquitin protein ligase family member 2provided by HGNC
Primary source
HGNC:HGNC:8828
See related
Ensembl:ENSG00000139946 MIM:614798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See PELI2 in Genome Data Viewer
Location:
14q22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (56118329..56301586)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (56585039..56768241)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370512 Neighboring gene uncharacterized LOC105370513 Neighboring gene uncharacterized LOC107984656 Neighboring gene long intergenic non-protein coding RNA 2284 Neighboring gene uncharacterized LOC101927690

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer.
NHGRI GWA Catalog
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
NHGRI GWA Catalog
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-ubiquitin ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase pellino homolog 2
Names
RING-type E3 ubiquitin transferase pellino homolog 2
pellino homolog 2
pellino-2
protein pellino homolog 2
NP_067078.1
XP_005267947.1
XP_006720274.1
XP_011535292.1
XP_011535294.1
XP_016876967.1
XP_016876968.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021255.3NP_067078.1  E3 ubiquitin-protein ligase pellino homolog 2

    See identical proteins and their annotated locations for NP_067078.1

    Status: VALIDATED

    Source sequence(s)
    AF302502, AK025208, AL355073, AL709755, BC009476
    Consensus CDS
    CCDS9726.1
    UniProtKB/Swiss-Prot
    Q9HAT8
    UniProtKB/TrEMBL
    Q9H716
    Related
    ENSP00000267460.4, ENST00000267460.9
    Conserved Domains (1) summary
    pfam04710
    Location:12420
    Pellino; Pellino

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    56118329..56301586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267890.5XP_005267947.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X3

    Conserved Domains (1) summary
    pfam04710
    Location:12232
    Pellino; Pellino
  2. XM_011536990.2XP_011535292.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_011535292.1

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino; Pellino
  3. XM_011536992.3XP_011535294.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_011535294.1

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino; Pellino
  4. XM_017021479.1XP_016876968.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino; Pellino
  5. XM_017021478.1XP_016876967.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X1

    Conserved Domains (1) summary
    pfam04710
    Location:10407
    Pellino; Pellino
  6. XM_006720211.3XP_006720274.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_006720274.1

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino; Pellino
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