U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PELI2 pellino E3 ubiquitin protein ligase family member 2 [ Homo sapiens (human) ]

Gene ID: 57161, updated on 5-Aug-2022

Summary

Official Symbol
PELI2provided by HGNC
Official Full Name
pellino E3 ubiquitin protein ligase family member 2provided by HGNC
Primary source
HGNC:HGNC:8828
See related
Ensembl:ENSG00000139946 MIM:614798; AllianceGenome:HGNC:8828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PELI2 in Genome Data Viewer
Location:
14q22.3
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (56118411..56301524)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (50324186..50507449)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (56585129..56768242)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370512 Neighboring gene uncharacterized LOC105370513 Neighboring gene long intergenic non-protein coding RNA 2284 Neighboring gene uncharacterized LOC124903321

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer.
EBI GWAS Catalog
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
EBI GWAS Catalog
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
EBI GWAS Catalog
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-ubiquitin ligase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase pellino homolog 2
Names
RING-type E3 ubiquitin transferase pellino homolog 2
pellino homolog 2
pellino-2
protein pellino homolog 2
NP_067078.1
XP_005267947.1
XP_006720274.1
XP_011535292.1
XP_011535294.1
XP_016876967.1
XP_016876968.1
XP_047287568.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021255.3NP_067078.1  E3 ubiquitin-protein ligase pellino homolog 2

    See identical proteins and their annotated locations for NP_067078.1

    Status: VALIDATED

    Source sequence(s)
    AF302502, AK025208, AL355073, AL709755, BC009476
    Consensus CDS
    CCDS9726.1
    UniProtKB/Swiss-Prot
    B2RDY5, Q9HAT8
    UniProtKB/TrEMBL
    Q9H716
    Related
    ENSP00000267460.4, ENST00000267460.9
    Conserved Domains (1) summary
    pfam04710
    Location:12420
    Pellino

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    56118411..56301524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536990.3XP_011535292.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_011535292.1

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino
  2. XM_005267890.6XP_005267947.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X3

    Conserved Domains (1) summary
    pfam04710
    Location:12232
    Pellino; Pellino
  3. XM_011536992.4XP_011535294.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_011535294.1

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino
  4. XM_017021479.2XP_016876968.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino
  5. XM_017021478.2XP_016876967.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X1

    Conserved Domains (1) summary
    pfam04710
    Location:10407
    Pellino; Pellino
  6. XM_047431612.1XP_047287568.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

  7. XM_006720211.4XP_006720274.1  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_006720274.1

    Conserved Domains (1) summary
    pfam04710
    Location:1320
    Pellino

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    50324186..50507449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)