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SLURP1 secreted LY6/PLAUR domain containing 1 [ Homo sapiens (human) ]

Gene ID: 57152, updated on 9-Jun-2025
Official Symbol
SLURP1provided by HGNC
Official Full Name
secreted LY6/PLAUR domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18746
See related
Ensembl:ENSG00000126233 MIM:606119; AllianceGenome:HGNC:18746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARS; MDM; ANUP; ArsB; LY6LS; LY6-MT
Summary
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward esophagus (RPKM 167.7) See more
Orthologs
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See SLURP1 in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142740949..142742406, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143884338..143885795, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143822367..143823824, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member K Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19605 Neighboring gene thioesterase superfamily member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143819807-143820373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19607 Neighboring gene LY6/PLAUR domain containing 2 Neighboring gene uncharacterized LOC124902033 Neighboring gene LYNX1-SLURP2 readthrough Neighboring gene secreted LY6/PLAUR domain containing 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetylcholine receptor activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
secreted Ly-6/uPAR-related protein 1
Names
ARS(component B)-81/S
SLURP-1
anti-neoplastic urinary protein
lymphocyte antigen 6-like secreted
secreted Ly6/uPAR related protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011494.1 RefSeqGene

    Range
    5006..6463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020427.3NP_065160.1  secreted Ly-6/uPAR-related protein 1 precursor

    See identical proteins and their annotated locations for NP_065160.1

    Status: REVIEWED

    Source sequence(s)
    AC083841
    Consensus CDS
    CCDS6387.1
    UniProtKB/Swiss-Prot
    P55000, Q53YJ6, Q6PUA6, Q92483
    Related
    ENSP00000246515.1, ENST00000246515.2
    Conserved Domains (1) summary
    cd00117
    Location:23101
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142740949..142742406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    143884338..143885795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)