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SLURP1 secreted LY6/PLAUR domain containing 1 [ Homo sapiens (human) ]

Gene ID: 57152, updated on 11-Jun-2021

Summary

Official Symbol
SLURP1provided by HGNC
Official Full Name
secreted LY6/PLAUR domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18746
See related
Ensembl:ENSG00000126233 MIM:606119
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARS; MDM; ANUP; ArsB; LY6LS; LY6-MT
Summary
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward esophagus (RPKM 167.7) See more
Orthologs
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Genomic context

See SLURP1 in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (142740949..142742406, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143822367..143823824, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member K Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene thioesterase superfamily member 6 Neighboring gene LY6/PLAUR domain containing 2 Neighboring gene LYNX1-SLURP2 readthrough Neighboring gene secreted LY6/PLAUR domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
secreted Ly-6/uPAR-related protein 1
Names
ARS(component B)-81/S
SLURP-1
anti-neoplastic urinary protein
lymphocyte antigen 6-like secreted
secreted Ly6/uPAR related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011494.1 RefSeqGene

    Range
    5006..6463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020427.3NP_065160.1  secreted Ly-6/uPAR-related protein 1 precursor

    See identical proteins and their annotated locations for NP_065160.1

    Status: REVIEWED

    Source sequence(s)
    AC083841
    Consensus CDS
    CCDS6387.1
    UniProtKB/Swiss-Prot
    P55000
    Related
    ENSP00000246515.1, ENST00000246515.2
    Conserved Domains (1) summary
    cd00117
    Location:23101
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    142740949..142742406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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