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hmbox1a homeobox containing 1a [ Danio rerio (zebrafish) ]

Gene ID: 571508, updated on 15-Jul-2026
Official Symbol
hmbox1aprovided by ZNC
Official Full Name
homeobox containing 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-89
See related
Ensembl:ENSDARG00000027082 AllianceGenome:ZFIN:ZDB-GENE-050913-89
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hmbox1; zgc:114064
Summary
Predicted to enable double-stranded telomeric DNA binding activity. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human HMBOX1 (homeobox containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See hmbox1a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 17 NC_133192.1 (17558813..17586242, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 17 NC_007128.7 (16297404..16324559, complement)

Chromosome 17 - NC_133192.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488081 Neighboring gene kinesin family member 13Ba Neighboring gene potassium channel, subfamily K, member 13a Neighboring gene tyrosyl-DNA phosphodiesterase 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Park SJ, et al. Dev Dyn, 2024 Aug. PMID 38270285, Free PMC Article
  2. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC114064

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomeric repeat DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
homeobox-containing protein 1a
Names
homeobox containing 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030264.1 → NP_001025435.1  homeobox-containing protein 1a

    See identical proteins and their annotated locations for NP_001025435.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097126
    UniProtKB/TrEMBL
    A0A8M1N7J1, Q4V904
    Related
    ENSDARP00000037056.8, ENSDART00000030835.10
    Conserved Domains (2) summary
    cd00086
    Location:280 → 352
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:13 → 237
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133192.1 Reference GRCz12tu Primary Assembly

    Range
    17558813..17586242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467221.3 → XP_021322896.1  homeobox-containing protein 1a isoform X5

    UniProtKB/TrEMBL
    A0A8M9PKV6
    Conserved Domains (2) summary
    cd00086
    Location:280 → 352
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:13 → 237
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  2. XM_005169832.6 → XP_005169889.1  homeobox-containing protein 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BH49
    Conserved Domains (2) summary
    cd00086
    Location:280 → 352
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:13 → 237
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  3. XM_021467220.3 → XP_021322895.1  homeobox-containing protein 1a isoform X4

    UniProtKB/TrEMBL
    A0A8M9PNW0
    Conserved Domains (2) summary
    cd00086
    Location:280 → 352
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:13 → 237
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  4. XM_005169831.6 → XP_005169888.1  homeobox-containing protein 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BH68
    Conserved Domains (2) summary
    cd00086
    Location:280 → 352
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:13 → 237
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  5. XM_009292894.5 → XP_009291169.1  homeobox-containing protein 1a isoform X3

    UniProtKB/TrEMBL
    A0A8M3AU36
    Conserved Domains (2) summary
    cd00086
    Location:280 → 352
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:13 → 237
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
Nucleotide Protein Strain
Heading Accession and Version

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