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LYRM1 LYR motif containing 1 [ Homo sapiens (human) ]

Gene ID: 57149, updated on 15-Apr-2019

Summary

Official Symbol
LYRM1provided by HGNC
Official Full Name
LYR motif containing 1provided by HGNC
Primary source
HGNC:HGNC:25074
See related
Ensembl:ENSG00000102897 MIM:614709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A211C6.1
Summary
The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Ubiquitous expression in liver (RPKM 13.3), fat (RPKM 11.4) and 25 other tissues See more
Orthologs

Genomic context

See LYRM1 in Genome Data Viewer
Location:
16p12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (20899626..20925006)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20911204..20936328)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase medium chain family member 3 Neighboring gene RNA, U6 small nuclear 944, pseudogene Neighboring gene ERI1 exoribonuclease family member 2 Neighboring gene uncharacterized LOC105371121 Neighboring gene RNA exonuclease 5 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene dynein axonemal heavy chain 3 Neighboring gene uncharacterized LOC107984888 Neighboring gene transmembrane protein 159

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
midbody IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
LYR motif-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128301.3NP_001121773.1  LYR motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001121773.1

    Status: REVIEWED

    Source sequence(s)
    AC002394
    Consensus CDS
    CCDS10593.1
    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Related
    ENSP00000219168.4, ENST00000219168.8
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  2. NM_001128302.3NP_001121774.1  LYR motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001121774.1

    Status: REVIEWED

    Source sequence(s)
    AL359616, BI547471, CX163936
    Consensus CDS
    CCDS10593.1
    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Related
    ENSP00000457333.1, ENST00000567954.6
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  3. NM_001302835.2NP_001289764.1  LYR motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001289764.1

    Status: REVIEWED

    Source sequence(s)
    AC002394
    Consensus CDS
    CCDS10593.1
    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Related
    ENSP00000379367.2, ENST00000396052.3
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  4. NM_001302836.2NP_001289765.1  LYR motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001289765.1

    Status: REVIEWED

    Source sequence(s)
    AC002394
    Consensus CDS
    CCDS10593.1
    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Related
    ENSP00000454551.1, ENST00000569023.5
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  5. NM_001369631.1NP_001356560.1  LYR motif-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002394
  6. NM_001369632.1NP_001356561.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  7. NM_001369633.1NP_001356562.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  8. NM_001369634.1NP_001356563.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  9. NM_001369635.1NP_001356564.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  10. NM_001369636.1NP_001356565.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  11. NM_001369637.1NP_001356566.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  12. NM_001369638.1NP_001356567.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  13. NM_001369639.1NP_001356568.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  14. NM_001369641.1NP_001356570.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  15. NM_001369642.1NP_001356571.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  16. NM_001369644.1NP_001356573.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  17. NM_001369645.1NP_001356574.1  LYR motif-containing protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002394
  18. NM_020424.5NP_065157.1  LYR motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_065157.1

    Status: REVIEWED

    Source sequence(s)
    AC002394
    Consensus CDS
    CCDS10593.1
    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Related
    ENSP00000454826.1, ENST00000568663.5
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)

RNA

  1. NR_126516.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  2. NR_126520.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
    Related
    ENST00000412082.6
  3. NR_126521.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  4. NR_126527.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  5. NR_126528.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  6. NR_161425.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  7. NR_161426.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  8. NR_161427.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  9. NR_161429.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  10. NR_161430.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  11. NR_161431.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394
  12. NR_161432.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002394

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    20899626..20925006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023477.1XP_016878966.1  LYR motif-containing protein 1 isoform X3

  2. XM_017023476.1XP_016878965.1  LYR motif-containing protein 1 isoform X2

  3. XM_017023475.1XP_016878964.1  LYR motif-containing protein 1 isoform X1

  4. XM_011545902.1XP_011544204.1  LYR motif-containing protein 1 isoform X4

    Conserved Domains (1) summary
    pfam13232
    Location:778
    Complex1_LYR_1; Complex1_LYR-like
  5. XM_024450359.1XP_024306127.1  LYR motif-containing protein 1 isoform X5

    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  6. XM_011545908.2XP_011544210.1  LYR motif-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011544210.1

    Conserved Domains (1) summary
    pfam13232
    Location:778
    Complex1_LYR_1; Complex1_LYR-like
  7. XM_017023480.1XP_016878969.1  LYR motif-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  8. XM_005255444.1XP_005255501.1  LYR motif-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  9. XM_011545901.2XP_011544203.1  LYR motif-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011544203.1

    Conserved Domains (1) summary
    pfam13232
    Location:778
    Complex1_LYR_1; Complex1_LYR-like
  10. XM_024450358.1XP_024306126.1  LYR motif-containing protein 1 isoform X5

    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  11. XM_011545900.2XP_011544202.1  LYR motif-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011544202.1

    Conserved Domains (1) summary
    pfam13232
    Location:778
    Complex1_LYR_1; Complex1_LYR-like
  12. XM_017023481.2XP_016878970.1  LYR motif-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  13. XM_017023479.2XP_016878968.1  LYR motif-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  14. XM_017023482.1XP_016878971.1  LYR motif-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    O43325
    UniProtKB/TrEMBL
    A0A024R3C2
    Conserved Domains (1) summary
    pfam05347
    Location:767
    Complex1_LYR; Complex 1 protein (LYR family)
  15. XM_017023478.1XP_016878967.1  LYR motif-containing protein 1 isoform X4

    Conserved Domains (1) summary
    pfam13232
    Location:778
    Complex1_LYR_1; Complex1_LYR-like

RNA

  1. XR_950823.2 RNA Sequence

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