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SCYL3 SCY1 like pseudokinase 3 [ Homo sapiens (human) ]

Gene ID: 57147, updated on 23-Nov-2021

Summary

Official Symbol
SCYL3provided by HGNC
Official Full Name
SCY1 like pseudokinase 3provided by HGNC
Primary source
HGNC:HGNC:19285
See related
Ensembl:ENSG00000000457 MIM:608192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PACE1; PACE-1
Summary
This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in lymph node (RPKM 4.6), testis (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See SCYL3 in Genome Data Viewer
Location:
1q24.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (169849631..169894267, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169818772..169863037, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928628 Neighboring gene chromosome 1 open reading frame 112 Neighboring gene methyltransferase like 18 Neighboring gene RNA, 7SL, cytoplasmic 333, pseudogene Neighboring gene VISTA enhancer hs1442 Neighboring gene kinesin associated protein 3 Neighboring gene RNA, 7SL, cytoplasmic 269, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in spinal cord motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein-associating with the carboxyl-terminal domain of ezrin
Names
SCY1-like 3
SCY1-like protein 3
SCY1-like, kinase-like 3
ezrin-binding partner PACE-1 (PACE-1)
ezrin-binding protein PACE-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020423.7NP_065156.5  protein-associating with the carboxyl-terminal domain of ezrin isoform 1

    See identical proteins and their annotated locations for NP_065156.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AL031297, AL117233, DA449356
    Consensus CDS
    CCDS1286.1
    UniProtKB/Swiss-Prot
    Q8IZE3
    Related
    ENSP00000356745.5, ENST00000367771.11
    Conserved Domains (3) summary
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    sd00044
    Location:294319
    HEAT; HEAT repeat [structural motif]
  2. NM_181093.4NP_851607.2  protein-associating with the carboxyl-terminal domain of ezrin isoform 2

    See identical proteins and their annotated locations for NP_851607.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2, which is longer than isoform 1.
    Source sequence(s)
    AK292507, AL031297, AL117233
    Consensus CDS
    CCDS1287.1
    UniProtKB/Swiss-Prot
    Q8IZE3
    Related
    ENSP00000356746.4, ENST00000367772.8
    Conserved Domains (3) summary
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    sd00044
    Location:294319
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    169849631..169894267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001863.1XP_016857352.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X2

    UniProtKB/Swiss-Prot
    Q8IZE3
    Related
    ENSP00000407993.1, ENST00000423670.1
    Conserved Domains (3) summary
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    sd00044
    Location:294319
    HEAT; HEAT repeat [structural motif]
  2. XM_011509801.1XP_011508103.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X1

    See identical proteins and their annotated locations for XP_011508103.1

    UniProtKB/Swiss-Prot
    Q8IZE3
    Conserved Domains (3) summary
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    sd00044
    Location:294319
    HEAT; HEAT repeat [structural motif]
  3. XM_024448565.1XP_024304333.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X5

  4. XM_017001864.1XP_016857353.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X4

    Conserved Domains (2) summary
    sd00044
    Location:152177
    HEAT; HEAT repeat [structural motif]
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011509802.1XP_011508104.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X3

    See identical proteins and their annotated locations for XP_011508104.1

    Conserved Domains (2) summary
    sd00044
    Location:152177
    HEAT; HEAT repeat [structural motif]
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017001865.1XP_016857354.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X4

    Conserved Domains (2) summary
    sd00044
    Location:152177
    HEAT; HEAT repeat [structural motif]
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017001862.1XP_016857351.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X2

    UniProtKB/Swiss-Prot
    Q8IZE3
    Conserved Domains (3) summary
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    sd00044
    Location:294319
    HEAT; HEAT repeat [structural motif]
  8. XM_006711465.1XP_006711528.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X1

    See identical proteins and their annotated locations for XP_006711528.1

    UniProtKB/Swiss-Prot
    Q8IZE3
    Related
    ENSP00000356744.1, ENST00000367770.5
    Conserved Domains (3) summary
    cd14011
    Location:9247
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    pfam00069
    Location:26245
    Pkinase; Protein kinase domain
    sd00044
    Location:294319
    HEAT; HEAT repeat [structural motif]
  9. XM_011509803.1XP_011508105.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X3

    See identical proteins and their annotated locations for XP_011508105.1

    Conserved Domains (2) summary
    sd00044
    Location:152177
    HEAT; HEAT repeat [structural motif]
    cl21453
    Location:1105
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001737336.2 RNA Sequence

  2. XR_001737335.2 RNA Sequence

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