gusb glucuronidase, beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gusbprovided by ZNC
Official Full Name: glucuronidase, betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-256
See related: Ensembl:ENSDARG00000063126 AllianceGenome:ZFIN:ZDB-GENE-070705-256
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ct573103.7; si:ch211-160e1.7
Summary: Predicted to enable beta-glucuronidase activity and carbohydrate binding activity. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in lysosome. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in mucopolysaccharidosis type VII. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	5	NC_133180.1 (2718213..2991348, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (2068883..2112087, complement)

Chromosome 5 - NC_133180.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables beta-glucuronidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-glucuronidase activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

XP_009299404.1

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The following sections contain reference sequences that belong to a specific genome build. Explain