U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADCK1 aarF domain containing kinase 1 [ Homo sapiens (human) ]

Gene ID: 57143, updated on 4-Dec-2022

Summary

Official Symbol
ADCK1provided by HGNC
Official Full Name
aarF domain containing kinase 1provided by HGNC
Primary source
HGNC:HGNC:19038
See related
Ensembl:ENSG00000063761 AllianceGenome:HGNC:19038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of mitochondrial fusion and positive regulation of cristae formation. Predicted to be located in extracellular region. Predicted to be active in mitochondrial inner membrane. Predicted to be integral component of mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 2.2), thyroid (RPKM 1.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ADCK1 in Genome Data Viewer
Location:
14q24.3
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (77800109..77935014)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (72009104..72144049)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (78266452..78401357)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene SRA stem-loop interacting RNA binding protein Neighboring gene SNW domain containing 1 Neighboring gene chromosome 14 open reading frame 178 Neighboring gene uncharacterized LOC105370581 Neighboring gene frataxin pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39600

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cristae formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aarF domain-containing protein kinase 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142545.2NP_001136017.1  aarF domain-containing protein kinase 1 isoform b

    See identical proteins and their annotated locations for NP_001136017.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC008372, AI866496, AK096919, BC017459, CD630155, DN996748
    Consensus CDS
    CCDS45144.1
    UniProtKB/Swiss-Prot
    Q86TW2
    Related
    ENSP00000339663.5, ENST00000341211.5
    Conserved Domains (1) summary
    cd13969
    Location:69301
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  2. NM_001366485.2NP_001353414.1  aarF domain-containing protein kinase 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC008372
    Conserved Domains (1) summary
    cd13969
    Location:117330
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  3. NM_001366486.2NP_001353415.1  aarF domain-containing protein kinase 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC008372
    Conserved Domains (1) summary
    cd13969
    Location:117338
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  4. NM_001366487.2NP_001353416.1  aarF domain-containing protein kinase 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC008372
    Conserved Domains (1) summary
    cd13969
    Location:117426
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  5. NM_001366488.2NP_001353417.1  aarF domain-containing protein kinase 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC008372
    Conserved Domains (1) summary
    cd13969
    Location:117299
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  6. NM_001366489.2NP_001353418.1  aarF domain-containing protein kinase 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC008372
    Conserved Domains (1) summary
    cd13969
    Location:117316
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  7. NM_001366490.2NP_001353419.1  aarF domain-containing protein kinase 1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC008372
    Conserved Domains (1) summary
    cd13969
    Location:1243
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  8. NM_020421.4NP_065154.2  aarF domain-containing protein kinase 1 isoform a precursor

    See identical proteins and their annotated locations for NP_065154.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC008372, AI866496, BC058906, CD630155
    Consensus CDS
    CCDS9869.1
    UniProtKB/Swiss-Prot
    Q86TW2
    Related
    ENSP00000238561.5, ENST00000238561.10
    Conserved Domains (1) summary
    cd13969
    Location:117369
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

RNA

  1. NR_158987.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008372
  2. NR_158988.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008372
  3. NR_158989.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008372

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    77800109..77935014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431611.1XP_047287567.1  aarF domain-containing protein kinase 1 isoform X2

  2. XM_047431610.1XP_047287566.1  aarF domain-containing protein kinase 1 isoform X1

  3. XM_017021477.2XP_016876966.1  aarF domain-containing protein kinase 1 isoform X2

    Conserved Domains (1) summary
    cd13969
    Location:1243
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
  4. XM_011536985.2XP_011535287.1  aarF domain-containing protein kinase 1 isoform X3

    Conserved Domains (2) summary
    cl28017
    Location:136226
    Herpes_UL37_1; Herpesvirus UL37 tegument protein
    cl21453
    Location:16142
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    72009104..72144049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)