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RGL3 ral guanine nucleotide dissociation stimulator like 3 [ Homo sapiens (human) ]

Gene ID: 57139, updated on 7-Jun-2020

Summary

Official Symbol
RGL3provided by HGNC
Official Full Name
ral guanine nucleotide dissociation stimulator like 3provided by HGNC
Primary source
HGNC:HGNC:30282
See related
Ensembl:ENSG00000205517 MIM:616743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in thyroid (RPKM 19.9), kidney (RPKM 13.4) and 17 other tissues See more
Orthologs

Genomic context

See RGL3 in Genome Data Viewer
Location:
19p13.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11394060..11419314, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11504732..11530018, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SWIM-type zinc finger 7 associated protein 1 Neighboring gene erythropoietin receptor Neighboring gene coiled-coil domain containing 151 Neighboring gene protein kinase C substrate 80K-H Neighboring gene ELAV like RNA binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: EPOR

Homology

Clone Names

  • FLJ00153, FLJ32585, FLJ44275, MGC126805, MGC138163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ral guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ral guanine nucleotide dissociation stimulator-like 3
Names
RalGEF-like protein 3, mouse homolog
ralGDS-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035223.4NP_001030300.3  ral guanine nucleotide dissociation stimulator-like 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    BC101756, BC143530, BM992649
    Consensus CDS
    CCDS32910.1
    UniProtKB/Swiss-Prot
    Q3MIN7
    UniProtKB/TrEMBL
    A0A0A0MRX4
    Related
    ENSP00000369823.3, ENST00000380456.7
    Conserved Domains (3) summary
    cd06224
    Location:74196
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00153
    Location:613698
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:243505
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
  2. NM_001161616.3NP_001155088.2  ral guanine nucleotide dissociation stimulator-like 3 isoform 1

    See identical proteins and their annotated locations for NP_001155088.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC143530, BM992649
    Consensus CDS
    CCDS54221.1
    UniProtKB/Swiss-Prot
    Q3MIN7
    Related
    ENSP00000377075.3, ENST00000393423.7
    Conserved Domains (3) summary
    cd06224
    Location:74196
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00153
    Location:619704
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:243505
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11394060..11419314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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