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APMAP adipocyte plasma membrane associated protein [ Homo sapiens (human) ]

Gene ID: 57136, updated on 7-Apr-2025

Summary

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Official Symbol
APMAPprovided by HGNC
Official Full Name
adipocyte plasma membrane associated proteinprovided by HGNC
Primary source
HGNC:HGNC:13238
See related
Ensembl:ENSG00000101474 MIM:615884; AllianceGenome:HGNC:13238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BSCv; C20orf3
Summary
Enables arylesterase activity. Predicted to be involved in biosynthetic process. Located in cell surface and membrane. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in thyroid (RPKM 46.5), fat (RPKM 34.1) and 24 other tissues See more
Orthologs
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Genomic context

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See APMAP in Genome Data Viewer
Location:
20p11.21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (24962925..24992751, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (25027196..25056965, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (24943561..24973387, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24899137-24899770 Neighboring gene long intergenic non-protein coding RNA 2967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17653 Neighboring gene cystatin F Neighboring gene RNA, U6 small nuclear 1257, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24960021-24960521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:24961283-24961783 Neighboring gene H3K27ac hESC enhancers GRCh37_chr20:24972940-24973440 and GRCh37_chr20:24973441-24973941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17657 Neighboring gene acyl-CoA synthetase short chain family member 1 Neighboring gene Sharpr-MPRA regulatory region 14776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25038651-25039256 Neighboring gene uncharacterized LOC124904882

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Identification of a Novel Function of Adipocyte Plasma Membrane-Associated Protein (APMAP) in Gestational Diabetes Mellitus by Proteomic Analysis of Omental Adipose Tissue. Ma Y, et al. J Proteome Res, 2016 Feb 5. PMID 26767403
  2. Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells. Haley SA, et al. Virology, 2020 Sep. PMID 32838939, Free PMC Article
  3. The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain. Mosser S, et al. Hum Mol Genet, 2015 Jan 15. PMID 25180020, Free PMC Article
  4. Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection. Ye X, et al. PLoS Pathog, 2019 Jul. PMID 31356650, Free PMC Article
  5. Chromosome 20p11 gains are associated with liver-specific metastasis in patients with colorectal cancer. Mekenkamp LJ, et al. Gut, 2013 Jan. PMID 22267596

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
    Title: Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
  2. Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells.
    Title: Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells.
  3. results suggest that APMAP functions as a modulator promoting human cytomegalovirus (HCMV) infection in multiple cell types and is an important player in the complex HCMV infection mechanism
    Title: Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection.
  4. These data suggest that APMAP is a novel regulator of extracellular matrix components, and establish that APMAP is a potential target to mitigate obesity-associated insulin resistance.
    Title: APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion.
  5. APMAP is an endogenous suppressor of Abeta production in the brain.
    Title: The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.
  6. C20orf3 mapping at chromosome 20p11 is associated with hepatic-specific metastasis in patients with colorectal cancer.
    Title: Chromosome 20p11 gains are associated with liver-specific metastasis in patients with colorectal cancer.
  7. characterization of the gene product of open reading frame 3 encoded at human chromosome 20 (C20orf3), which represents a member of the lactonohydrolase super family
    Title: Localization and characterization of the novel protein encoded by C20orf3.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adipocyte plasma membrane-associated protein
Names
protein BSCv

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020531.3 → NP_065392.1  adipocyte plasma membrane-associated protein

    See identical proteins and their annotated locations for NP_065392.1

    Status: VALIDATED

    Source sequence(s)
    AK026866, AL035661, BG773501, CF131759
    Consensus CDS
    CCDS13166.1
    UniProtKB/Swiss-Prot
    A8K514, B4DXG1, Q6UVZ8, Q9GZS8, Q9HDC9, Q9NUB2
    UniProtKB/TrEMBL
    H0Y512
    Related
    ENSP00000217456.2, ENST00000217456.3
    Conserved Domains (4) summary
    COG3386
    Location:73 → 320
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd05819
    Location:102 → 137
    NHL; NHL repeat [structural motif]
    cl18310
    Location:96 → 284
    NHL; NHL repeat unit of beta-propeller proteins
    cl22863
    Location:201 → 288
    Str_synth; Strictosidine synthase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    24962925..24992751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260763.4 → XP_005260820.1  adipocyte plasma membrane-associated protein isoform X1

    UniProtKB/Swiss-Prot
    Q9HDC9
    Conserved Domains (3) summary
    cd05819
    Location:102 → 137
    NHL; NHL repeat [structural motif]
    cl18310
    Location:96 → 282
    NHL; NHL repeat unit of beta-propeller proteins
    cl22863
    Location:201 → 287
    Str_synth; Strictosidine synthase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    25027196..25056965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323725.1 → XP_054179700.1  adipocyte plasma membrane-associated protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HDC9.2 GenPept UniProtKB/Swiss-Prot:Q9HDC9

Gene LinkOut

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