Format

Send to:

Choose Destination

MRPL47 mitochondrial ribosomal protein L47 [ Homo sapiens (human) ]

Gene ID: 57129, updated on 1-Jun-2020

Summary

Official Symbol
MRPL47provided by HGNC
Official Full Name
mitochondrial ribosomal protein L47provided by HGNC
Primary source
HGNC:HGNC:16652
See related
Ensembl:ENSG00000136522 MIM:611852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCM1; L47mt; CGI-204; MRP-L47
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 23.3), heart (RPKM 16.9) and 25 other tissues See more
Orthologs

Genomic context

See MRPL47 in Genome Data Viewer
Location:
3q26.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (179588285..179604646, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (179306253..179322434, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 7 Neighboring gene uncharacterized LOC107986157 Neighboring gene actin like 6A Neighboring gene NADH:ubiquinone oxidoreductase subunit B5 Neighboring gene H3 histone pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ACTL6A

Homology

Clone Names

  • MGC45403

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L47, mitochondrial
Names
mitochondrial large ribosomal subunit protein uL29m
nasopharyngeal carcinoma metastasis-related 1
nasopharyngeal carcinoma metastasis-related protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020409.3NP_065142.2  39S ribosomal protein L47, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_065142.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and it encodes isoform a.
    Source sequence(s)
    AC090425, AY212270, BC021575, BC032522
    Consensus CDS
    CCDS3232.1
    UniProtKB/Swiss-Prot
    Q9HD33
    Related
    ENSP00000417602.1, ENST00000476781.6
    Conserved Domains (1) summary
    pfam06984
    Location:64149
    MRP-L47; Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
  2. NM_177988.1NP_817125.1  39S ribosomal protein L47, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_817125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment, compared to variant 1, which leads to the use of a downstream start codon. The predicted protein (isoform b) is shorter than isoform a. The predicted ORF of this transcript has not been experimentally confirmed.
    Source sequence(s)
    BC021575, BC032522
    Consensus CDS
    CCDS3233.1
    UniProtKB/Swiss-Prot
    Q9HD33
    Related
    ENSP00000376427.2, ENST00000392659.2
    Conserved Domains (1) summary
    cl09943
    Location:139
    Ribosomal_L29_HIP; Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    179588285..179604646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center