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CD177 CD177 molecule [ Homo sapiens (human) ]

Gene ID: 57126, updated on 18-Aug-2020

Summary

Official Symbol
CD177provided by HGNC
Official Full Name
CD177 moleculeprovided by HGNC
Primary source
HGNC:HGNC:30072
See related
Ensembl:ENSG00000204936 MIM:162860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP
Summary
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
Expression
Biased expression in bone marrow (RPKM 83.5), colon (RPKM 72.9) and 1 other tissue See more
Orthologs

Genomic context

See CD177 in Genome Data Viewer
Location:
19q13.31
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43353686..43366063)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43857825..43867480)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule pseudogene 4 Neighboring gene p53-responsive gene 1 Neighboring gene CD177 molecule pseudogene 1 Neighboring gene testis expressed 101 Neighboring gene RNA, 28S ribosomal pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell junction maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
neutrophil extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neutrophil degranulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neutrophil degranulation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of superoxide anion generation IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
anchored component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
plasma membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CD177 antigen
Names
NB1 glycoprotein
cell surface receptor
human neutrophil alloantigen 2a
polycythemia rubra vera protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020406.4NP_065139.2  CD177 antigen precursor

    See identical proteins and their annotated locations for NP_065139.2

    Status: REVIEWED

    Source sequence(s)
    AK225226, AY358932, BC029167, BU688145, CD514938, DA728784, DB323632
    Consensus CDS
    CCDS62700.1
    UniProtKB/Swiss-Prot
    Q8N6Q3
    UniProtKB/TrEMBL
    A0A087WVM2
    Related
    ENSP00000479536.1, ENST00000618265.5
    Conserved Domains (2) summary
    pfam00021
    Location:133203
    UPAR_LY6; u-PAR/Ly-6 domain
    cl10471
    Location:325394
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43353686..43366063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027021.2XP_016882510.1  CD177 antigen isoform X1

  2. XM_017027022.2XP_016882511.1  CD177 antigen isoform X2

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