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LPAR5 lysophosphatidic acid receptor 5 [ Homo sapiens (human) ]

Gene ID: 57121, updated on 8-Aug-2021

Summary

Official Symbol
LPAR5provided by HGNC
Official Full Name
lysophosphatidic acid receptor 5provided by HGNC
Primary source
HGNC:HGNC:13307
See related
Ensembl:ENSG00000184574 MIM:606926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPA5; GPR92; GPR93; KPG_010
Summary
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
Expression
Broad expression in colon (RPKM 5.6), lymph node (RPKM 4.4) and 23 other tissues See more
Orthologs
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Genomic context

See LPAR5 in Genome Data Viewer
Location:
12p13.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6618835..6635959, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6728001..6745125, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene CRISPRi-validated cis-regulatory element chr12.325 Neighboring gene uncharacterized LOC105369631 Neighboring gene acrosin binding protein Neighboring gene inhibitor of growth family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ACRBP

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral response to pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biological_process ND
No biological Data available
more info
 
involved_in positive regulation of CREB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lysophosphatidic acid receptor 5
Names
G protein-coupled receptor 92
G-protein coupled receptor 93
LPA receptor 5
LPA-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142961.1NP_001136433.1  lysophosphatidic acid receptor 5

    See identical proteins and their annotated locations for NP_001136433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC072394, DC328599
    Consensus CDS
    CCDS8553.1
    UniProtKB/Swiss-Prot
    Q9H1C0
    UniProtKB/TrEMBL
    Q5KU18
    Related
    ENSP00000393098.1, ENST00000431922.1
    Conserved Domains (2) summary
    cd14964
    Location:2549
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23308
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_020400.6NP_065133.1  lysophosphatidic acid receptor 5

    See identical proteins and their annotated locations for NP_065133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC072394
    Consensus CDS
    CCDS8553.1
    UniProtKB/Swiss-Prot
    Q9H1C0
    UniProtKB/TrEMBL
    Q5KU18
    Related
    ENSP00000327875.4, ENST00000329858.9
    Conserved Domains (2) summary
    cd14964
    Location:2549
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23308
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6618835..6635959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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