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ZNF695 zinc finger protein 695 [ Homo sapiens (human) ]

Gene ID: 57116, updated on 5-Jan-2022

Summary

Official Symbol
ZNF695provided by HGNC
Official Full Name
zinc finger protein 695provided by HGNC
Primary source
HGNC:HGNC:30954
See related
Ensembl:ENSG00000197472 MIM:616348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBZF3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZNF695 in Genome Data Viewer
Location:
1q44
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (246945546..247008057, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247108848..247171359, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1341 Neighboring gene AT-hook containing transcription factor 1 Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene Sharpr-MPRA regulatory region 11618 Neighboring gene zinc finger protein 519 pseudogene Neighboring gene DNA primase subunit 1 pseudogene Neighboring gene zinc finger protein 670

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZNF670-ZNF695

Readthrough gene: ZNF670-ZNF695, Included gene: ZNF670

Homology

Clone Names

  • MGC61907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 695
Names
zinc finger protein SBZF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204221.2NP_001191150.2  zinc finger protein 695 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113174, AL512637
    Consensus CDS
    CCDS55694.1
    Related
    ENSP00000429736.1, ENST00000487338.6
    Conserved Domains (1) summary
    smart00349
    Location:476
    KRAB; krueppel associated box
  2. NM_020394.5NP_065127.5  zinc finger protein 695 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL512637
    Consensus CDS
    CCDS44344.1
    Related
    ENSP00000341236.7, ENST00000339986.8
    Conserved Domains (3) summary
    smart00349
    Location:476
    KRAB; krueppel associated box
    COG5048
    Location:148515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:354374
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_037892.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate exon structure in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113174, AL512637
    Related
    ENST00000366504.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    246945546..247008057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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