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PGLYRP4 peptidoglycan recognition protein 4 [ Homo sapiens (human) ]

Gene ID: 57115, updated on 11-Jun-2021

Summary

Official Symbol
PGLYRP4provided by HGNC
Official Full Name
peptidoglycan recognition protein 4provided by HGNC
Primary source
HGNC:HGNC:30015
See related
Ensembl:ENSG00000163218 MIM:608198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGRPIB; SBBI67; PGRP-Ibeta; PGLYRPIbeta
Summary
Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
Expression
Biased expression in skin (RPKM 2.9) and esophagus (RPKM 1.0) See more
Orthologs
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Genomic context

See PGLYRP4 in Genome Data Viewer
Location:
1q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153327410..153348844, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153302596..153321317, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene loricrin cornified envelope precursor protein Neighboring gene peptidoglycan recognition protein 3 Neighboring gene RNA, U6 small nuclear 160, pseudogene Neighboring gene S100 calcium binding protein A9 Neighboring gene S100 calcium binding protein A12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of peptidoglycan recognition protein 4 (PGLYRP4) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidoglycan immune receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidoglycan recognition protein 4
Names
PGRP-I-beta
peptidoglycan recognition protein I-beta
peptidoglycan recognition protein intermediate beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020393.4NP_065126.2  peptidoglycan recognition protein 4 precursor

    See identical proteins and their annotated locations for NP_065126.2

    Status: REVIEWED

    Source sequence(s)
    AF242518, AK292203, BC142636
    Consensus CDS
    CCDS30871.1
    UniProtKB/Swiss-Prot
    Q96LB8
    Related
    ENSP00000352672.5, ENST00000359650.10
    Conserved Domains (1) summary
    smart00701
    Location:211351
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153327410..153348844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509791.2XP_011508093.1  peptidoglycan recognition protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q96LB8
    Related
    ENSP00000357728.3, ENST00000368739.3
    Conserved Domains (1) summary
    smart00701
    Location:207347
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  2. XM_011509789.2XP_011508091.1  peptidoglycan recognition protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011508091.1

    UniProtKB/Swiss-Prot
    Q96LB8
    Conserved Domains (1) summary
    smart00701
    Location:211351
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  3. XM_011509792.1XP_011508094.1  peptidoglycan recognition protein 4 isoform X3

    Conserved Domains (1) summary
    smart00701
    Location:53194
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  4. XM_011509793.2XP_011508095.1  peptidoglycan recognition protein 4 isoform X4

    Conserved Domains (1) summary
    smart00701
    Location:43183
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
  5. XM_011509790.1XP_011508092.1  peptidoglycan recognition protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011508092.1

    UniProtKB/Swiss-Prot
    Q96LB8
    Conserved Domains (1) summary
    smart00701
    Location:211351
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RNA

  1. XR_001737322.1 RNA Sequence

  2. XR_921897.2 RNA Sequence

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