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TRPC7 transient receptor potential cation channel subfamily C member 7 [ Homo sapiens (human) ]

Gene ID: 57113, updated on 7-Jun-2020

Summary

Official Symbol
TRPC7provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 7provided by HGNC
Primary source
HGNC:HGNC:20754
See related
Ensembl:ENSG00000069018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP7
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TRPC7 in Genome Data Viewer
Location:
5q31.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (136212745..136365545, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135548458..135701164, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene SMAD5 antisense RNA 1 Neighboring gene SMAD family member 5 Neighboring gene small integral membrane protein 32 Neighboring gene TRPC7 antisense RNA 2 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 18 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cis-Golgi network IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
short transient receptor potential channel 7
Names
likley ortholog of mouse transient receptor potential cation channel, subfamily C, member 7
putative capacitative calcium channel
transient receptor protein 7
NP_001161048.1
NP_001161049.1
NP_001363830.1
NP_065122.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167576.2NP_001161048.1  short transient receptor potential channel 7 isoform 3

    See identical proteins and their annotated locations for NP_001161048.1

    Status: VALIDATED

    Source sequence(s)
    AC008661
    Consensus CDS
    CCDS54905.1
    UniProtKB/Swiss-Prot
    Q9HCX4
    Related
    ENSP00000330322.5, ENST00000352189.8
    Conserved Domains (5) summary
    cd00204
    Location:51184
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27706
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:198256
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:77108
    ANK; ANK repeat [structural motif]
    cl00511
    Location:466549
    FTSW_RODA_SPOVE; Cell cycle protein
  2. NM_001167577.2NP_001161049.1  short transient receptor potential channel 7 isoform 2

    See identical proteins and their annotated locations for NP_001161049.1

    Status: VALIDATED

    Source sequence(s)
    AC008661
    Consensus CDS
    CCDS54906.1
    UniProtKB/Swiss-Prot
    Q9HCX4
    Related
    ENSP00000367720.3, ENST00000378459.7
    Conserved Domains (5) summary
    cd00204
    Location:51184
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27761
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:198256
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:77108
    ANK; ANK repeat [structural motif]
    cl00511
    Location:521604
    FTSW_RODA_SPOVE; Cell cycle protein
  3. NM_001376901.1NP_001363830.1  short transient receptor potential channel 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008661
    Related
    ENSP00000424854.3, ENST00000502753.4
  4. NM_020389.3NP_065122.1  short transient receptor potential channel 7 isoform 1

    See identical proteins and their annotated locations for NP_065122.1

    Status: VALIDATED

    Source sequence(s)
    AC008661
    Consensus CDS
    CCDS47267.2
    UniProtKB/Swiss-Prot
    Q9HCX4
    Related
    ENSP00000426070.1, ENST00000513104.5
    Conserved Domains (2) summary
    TIGR00870
    Location:27822
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:77108
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    136212745..136365545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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