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RAB25 RAB25, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 57111, updated on 27-Nov-2024

Summary

Official Symbol
RAB25provided by HGNC
Official Full Name
RAB25, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:18238
See related
Ensembl:ENSG00000132698 MIM:612942; AllianceGenome:HGNC:18238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CATX-8; RAB11C
Summary
The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Biased expression in esophagus (RPKM 128.3), skin (RPKM 60.6) and 12 other tissues See more
Orthologs
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Genomic context

See RAB25 in Genome Data Viewer
Location:
1q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156061160..156070504)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155199625..155208969)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156030951..156040295)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371729 Neighboring gene ubiquilin 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156022535-156023256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1836 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:156045982-156046889 and GRCh37_chr1:156046890-156047796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156051244-156052056 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156052057-156052870 Neighboring gene mex-3 RNA binding family member A Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156056191-156057025 Neighboring gene Sharpr-MPRA regulatory region 15377 Neighboring gene lamin A/C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156067261-156068134 Neighboring gene VISTA enhancer hs2129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156077037-156077778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1420 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156087275-156087774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156090429-156091415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156093390-156094377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1843 Neighboring gene Sharpr-MPRA regulatory region 4592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156096352-156097337 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:156099693-156100892

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in epithelial cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in pseudopodium organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in pseudopodium membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020387.4NP_065120.2  ras-related protein Rab-25 precursor

    See identical proteins and their annotated locations for NP_065120.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    BC009831, BP263750
    Consensus CDS
    CCDS41413.1
    UniProtKB/Swiss-Prot
    P57735, Q5VYA2, Q8NG24, Q96GB1, Q9BT12
    Related
    ENSP00000354376.5, ENST00000361084.10
    Conserved Domains (1) summary
    cd01868
    Location:11174
    Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RNA

  1. NR_133653.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC009831, BP263750, BP273992

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156061160..156070504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155199625..155208969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)