HRASLS HRAS like suppressor [Homo sapiens (human)] - Gene

Summary

Official Symbol: HRASLSprovided by HGNC
Official Full Name: HRAS like suppressorprovided by HGNC
Primary source: HGNC:HGNC:14922
See related: Ensembl:ENSG00000127252 MIM:606487; Vega:OTTHUMG00000156104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: A-C1; HRSL1; HSD28; HRASLS1; H-REV107
Expression: Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 3q29

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	3	NC_000003.12 (193241128..193281639)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (192948030..193025102)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

A novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided.
Title: Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.
The HRASLS (PLA/AT) subfamily of enzymes.
Title: The HRASLS (PLA/AT) subfamily of enzymes.
a possible enzyme activity of A-C1
Title: Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes.
The phospholipase active site possesses a structurally conserved Cys-His-His triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases.
Title: Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Acyl chain remodelling of PE, organism-specific biosystem (from REACTOME)
Acyl chain remodelling of PE, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid ...
Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
Phospholipid metabolism, organism-specific biosystem (from REACTOME)
Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HRASLS (e-PCR)
- UniSTS:505530

SHGC-110035 (e-PCR)
- UniSTS:170178

Homology

Homologs of the HRASLS gene: The HRASLS gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 185 organisms have orthologs with human gene HRASLS
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
N-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
lipid catabolic process	IEA Inferred from Electronic Annotation more info
phosphatidylcholine metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
integral component of membrane	IEA Inferred from Electronic Annotation more info
nuclear envelope lumen	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phospholipid-metabolizing enzyme A-C1

Names: H-REV107 protein-related protein; HRAS-like suppressor 1; phospholipase A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001366112.1 → NP_001353041.1 phospholipid-metabolizing enzyme A-C1

Status: VALIDATED

Source sequence(s)

AC092966, AC105057
NM_020386.5 → NP_065119.3 phospholipid-metabolizing enzyme A-C1

Status: VALIDATED

Source sequence(s)

BC048095, BX098792

Consensus CDS

CCDS3303.2

Related

ENSP00000264735.3, ENST00000264735.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p12 Primary Assembly

Range

193241128..193281639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011513035.2 → XP_011511337.1 phospholipid-metabolizing enzyme A-C1 isoform X2

Conserved Domains (1) summary

pfam04970
Location:131 → 235

LRAT; Lecithin retinol acyltransferase
XM_011513034.1 → XP_011511336.1 phospholipid-metabolizing enzyme A-C1 isoform X1

Conserved Domains (1) summary

pfam04970
Location:131 → 235

LRAT; Lecithin retinol acyltransferase
XM_017006923.1 → XP_016862412.1 phospholipid-metabolizing enzyme A-C1 isoform X3

UniProtKB/Swiss-Prot

Q9HDD0

Conserved Domains (1) summary

pfam04970
Location:26 → 130

LRAT; Lecithin retinol acyltransferase