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HRASLS HRAS like suppressor [ Homo sapiens (human) ]

Gene ID: 57110, updated on 26-Sep-2018

Summary

Official Symbol
HRASLSprovided by HGNC
Official Full Name
HRAS like suppressorprovided by HGNC
Primary source
HGNC:HGNC:14922
See related
Ensembl:ENSG00000127252 MIM:606487; Vega:OTTHUMG00000156104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A-C1; HRSL1; HSD28; HRASLS1; H-REV107
Expression
Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues See more
Orthologs

Genomic context

See HRASLS in Genome Data Viewer
Location:
3q29
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (193241128..193281639)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (192948030..193025102)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vascular endothelial zinc finger 1 pseudogene 1 Neighboring gene uncharacterized LOC105374280 Neighboring gene uncharacterized protein MGC2889 Neighboring gene ATPase 13A5 Neighboring gene ATP13A5 antisense RNA 1 Neighboring gene ATPase 13A4 Neighboring gene ATP13A4 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Acyl chain remodelling of PE, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PE, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid ...
  • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
    Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope lumen ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
phospholipid-metabolizing enzyme A-C1
Names
H-REV107 protein-related protein
HRAS-like suppressor 1
phospholipase A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366112.1NP_001353041.1  phospholipid-metabolizing enzyme A-C1

    Status: VALIDATED

    Source sequence(s)
    AC092966, AC105057
  2. NM_020386.5NP_065119.3  phospholipid-metabolizing enzyme A-C1

    Status: VALIDATED

    Source sequence(s)
    BC048095, BX098792
    Consensus CDS
    CCDS3303.2
    Related
    ENSP00000264735.3, ENST00000264735.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    193241128..193281639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513035.2XP_011511337.1  phospholipid-metabolizing enzyme A-C1 isoform X2

    Conserved Domains (1) summary
    pfam04970
    Location:131235
    LRAT; Lecithin retinol acyltransferase
  2. XM_011513034.1XP_011511336.1  phospholipid-metabolizing enzyme A-C1 isoform X1

    Conserved Domains (1) summary
    pfam04970
    Location:131235
    LRAT; Lecithin retinol acyltransferase
  3. XM_017006923.1XP_016862412.1  phospholipid-metabolizing enzyme A-C1 isoform X3

    UniProtKB/Swiss-Prot
    Q9HDD0
    Conserved Domains (1) summary
    pfam04970
    Location:26130
    LRAT; Lecithin retinol acyltransferase
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