PLAAT1 phospholipase A and acyltransferase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLAAT1provided by HGNC
Official Full Name: phospholipase A and acyltransferase 1provided by HGNC
Primary source: HGNC:HGNC:14922
See related: Ensembl:ENSG00000127252 MIM:606487
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: A-C1; HRSL1; HSD28; HRASLS; HRASLS1; PLA/AT1; PLAAT-1; H-REV107
Expression: Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q29

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	3	NC_000003.12 (193241128..193281639)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (192959011..192988644)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided.
Title: Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.
The HRASLS (PLA/AT) subfamily of enzymes.
Title: The HRASLS (PLA/AT) subfamily of enzymes.
a possible enzyme activity of A-C1
Title: Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes.
The phospholipase active site possesses a structurally conserved Cys-His-His triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases.
Title: Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HRASLS (e-PCR)
- UniSTS:505530

SHGC-110035 (e-PCR)
- UniSTS:170178

Homology

Homologs of the PLAAT1 gene: The PLAAT1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 345 organisms have orthologs with human gene PLAAT1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables N-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-acylphosphatidylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in N-acylphosphatidylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lens fiber cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in organelle disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in integral component of membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope lumen	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase A and acyltransferase 1

Names: H-REV107 protein-related protein; HRAS like suppressor; HRAS-like suppressor 1; phospholipase A/acyltransferase 1; phospholipid-metabolizing enzyme A-C1

NP_001353041.1

EC 3.1.1.32

EC 3.1.1.4

NP_065119.3

EC 3.1.1.32

EC 3.1.1.4

XP_011511336.1

EC 3.1.1.32

EC 3.1.1.4

XP_011511337.1

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001366112.1 → NP_001353041.1 phospholipase A and acyltransferase 1

Status: VALIDATED

Source sequence(s)

AC092966, AC105057

Conserved Domains (1) summary

pfam04970
Location:26 → 130

LRAT; Lecithin retinol acyltransferase
NM_020386.5 → NP_065119.3 phospholipase A and acyltransferase 1

Status: VALIDATED

Source sequence(s)

BC048095, BX098792

Consensus CDS

CCDS3303.2

Related

ENSP00000264735.4, ENST00000264735.4

Conserved Domains (1) summary

pfam04970
Location:26 → 130

LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p13 Primary Assembly

Range

193241128..193281639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011513035.2 → XP_011511337.1 phospholipase A and acyltransferase 1 isoform X2

Conserved Domains (1) summary

pfam04970
Location:132 → 235

LRAT; Lecithin retinol acyltransferase
XM_011513034.1 → XP_011511336.1 phospholipase A and acyltransferase 1 isoform X1

Conserved Domains (1) summary

pfam04970
Location:132 → 235

LRAT; Lecithin retinol acyltransferase