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PSMD5 proteasome 26S subunit, non-ATPase 5 [ Homo sapiens (human) ]

Gene ID: 5711, updated on 6-Sep-2022


Official Symbol
PSMD5provided by HGNC
Official Full Name
proteasome 26S subunit, non-ATPase 5provided by HGNC
Primary source
See related
Ensembl:ENSG00000095261 MIM:604452; AllianceGenome:HGNC:9563
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]
Ubiquitous expression in urinary bladder (RPKM 4.7), adrenal (RPKM 4.2) and 25 other tissues See more
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Genomic context

See PSMD5 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (120816053..120842922, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (133012210..133039081, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123578331..123605200, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 2 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene Sharpr-MPRA regulatory regions 2033 and 13781 Neighboring gene cutA divalent cation tolerance like, pseudogene Neighboring gene PHD finger protein 19 Neighboring gene CRISPRi-validated cis-regulatory element chr9.2278

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • KIAA0072, MGC23145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in proteasome regulatory particle assembly IDA
Inferred from Direct Assay
more info
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
located_in nucleoplasm TAS
Traceable Author Statement
more info
part_of proteasome accessory complex ISS
Inferred from Sequence or Structural Similarity
more info
part_of proteasome complex TAS
Traceable Author Statement
more info

General protein information

Preferred Names
26S proteasome non-ATPase regulatory subunit 5
26S protease subunit S5 basic
26S proteasome subunit S5B
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270427.2NP_001257356.1  26S proteasome non-ATPase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001257356.1

    Status: REVIEWED

    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK303007, BC014478, D31889
    Consensus CDS
    ENSP00000363011.5, ENST00000373904.5
    Conserved Domains (1) summary
    Proteasom_PSMB; Proteasome non-ATPase 26S subunit
  2. NM_005047.4NP_005038.1  26S proteasome non-ATPase regulatory subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_005038.1

    Status: REVIEWED

    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC014478, D31889, HY023459
    Consensus CDS
    Q16401, Q4VXG8
    ENSP00000210313.2, ENST00000210313.8
    Conserved Domains (2) summary
    HEAT; HEAT repeat [structural motif]
    Proteasom_PSMB; Proteasome non-ATPase 26S subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    120816053..120842922 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060933.1 Alternate T2T-CHM13v2.0

    133012210..133039081 complement
    GenBank, FASTA, Sequence Viewer (Graphics)