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CYSLTR2 cysteinyl leukotriene receptor 2 [ Homo sapiens (human) ]

Gene ID: 57105, updated on 3-May-2025
Official Symbol
CYSLTR2provided by HGNC
Official Full Name
cysteinyl leukotriene receptor 2provided by HGNC
Primary source
HGNC:HGNC:18274
See related
Ensembl:ENSG00000152207 MIM:605666; AllianceGenome:HGNC:18274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146
Summary
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues See more
Orthologs
mouse all
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See CYSLTR2 in Genome Data Viewer
Location:
13q14.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (48653929..48711226)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (47874204..47931486)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49228065..49285362)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7736 Neighboring gene long intergenic non-protein coding RNA 1077 Neighboring gene uncharacterized LOC105370202 Neighboring gene Sharpr-MPRA regulatory region 13035 Neighboring gene long intergenic non-protein coding RNA 462 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:49323510-49324709 Neighboring gene proteasome activator subunit 2 pseudogene 2 Neighboring gene uncharacterized LOC107984559 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:49447591-49448313 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:49449130-49449638 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:49449639-49450147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7737

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Moore AR, et al. Nat Genet, 2016 Jun. PMID 27089179, Free PMC Article
  2. Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization. Shin JA, et al. BMC Med Genet, 2009 Oct 20. PMID 19840403, Free PMC Article
  3. Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor. Brochu-Bourque A, et al. J Pharmacol Exp Ther, 2011 Feb. PMID 20966037
  4. Hyperleukotrieneuria in patients with allergic and inflammatory disease. Taniguchi M, et al. Allergol Int, 2008 Dec. PMID 18946233
  5. Cysteinyl leukotriene receptor 2 gene polymorphism -1220 A/C is not associated with atopic dermatitis or psoriasis vulgaris in Japanese patients. Kato T, et al. J Dermatol, 2011 May. PMID 21352274

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The IL-31/CysLT2R axis is associated with itching in patients with allergic rhinitis.
    Title: The IL-31/CysLT2R axis is associated with itching in patients with allergic rhinitis.
  2. DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
    Title: DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
  3. Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells.
    Title: Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells.
  4. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.
    Title: The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch.
  5. Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
    Title: Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
  6. Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.
    Title: Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.
  7. Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.
    Title: Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.
  8. findings indicate that CysLT2R was involved in inflammation and neuronal damage by inducing the activation of microglia M1 polarization and NF-kappaB pathway, inhibiting microglia M1 polarization and promoting microglia polarization toward M2 phenotype which may exerts neuroprotective effects.
    Title: Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway.
  9. Polymorphisms in the CYSLTR2 gene are associated with asthma, atopy markers and helminth infection in Brazilian individuals, which may lead to protection or risk for such conditions, however, more studies are needed to evaluate the functional of this variants here in described.
    Title: Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population.
  10. CYSLTR2-mutant melanocytic blue neoplasms frequently exhibit a heavily pigmented exophytic tumor with a silhouette resembling "pigmented epithelioid melanocytoma" rather than usual cellular blue nevus.
    Title: CYSLTR2-mutant Cutaneous Melanocytic Neoplasms Frequently Simulate "Pigmented Epithelioid Melanocytoma," Expanding the Morphologic Spectrum of Blue Tumors: A Clinicopathologic Study of 7 Cases.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteinyl leukotriene receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in leukotriene signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
Preferred Names
cysteinyl leukotriene receptor 2
Names
G-protein coupled receptor GPCR21
G-protein coupled receptor HG57
cysteinyl leukotriene CysLT2 receptor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051649.1 RefSeqGene

    Range
    5219..62516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308465.3 → NP_001295394.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (I) represents the longest transcript. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118, EF141523
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001308467.3 → NP_001295396.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295396.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (II) differs in the 5' UTR compared to variant 1. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118, EF141524
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001308468.3 → NP_001295397.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (III) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118, EF141525
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001308469.3 → NP_001295398.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118, EF141526
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_001308470.3 → NP_001295399.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118, EF141529
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. NM_001308471.3 → NP_001295400.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118, EF141530
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Related
    ENSP00000282018.3, ENST00000282018.4
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  7. NM_001308476.3 → NP_001295405.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (V) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118, EF141527
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Related
    ENSP00000508181.1, ENST00000682523.1
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  8. NM_001387012.1 → NP_001373941.1  cysteinyl leukotriene receptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  9. NM_001387013.1 → NP_001373942.1  cysteinyl leukotriene receptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  10. NM_001387014.1 → NP_001373943.1  cysteinyl leukotriene receptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AL137118
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  11. NM_020377.5 → NP_065110.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_065110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (VI) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
    Source sequence(s)
    AK291739, AL137118
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9HCQ2, Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Related
    ENSP00000477930.1, ENST00000614739.4
    Conserved Domains (1) summary
    cd15157
    Location:39 → 316
    7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    48653929..48711226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    47874204..47931486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS75.1 GenPept UniProtKB/Swiss-Prot:Q9NS75

Gene LinkOut

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