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CYSLTR2 cysteinyl leukotriene receptor 2 [ Homo sapiens (human) ]

Gene ID: 57105, updated on 3-May-2020

Summary

Official Symbol
CYSLTR2provided by HGNC
Official Full Name
cysteinyl leukotriene receptor 2provided by HGNC
Primary source
HGNC:HGNC:18274
See related
Ensembl:ENSG00000152207 MIM:605666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146
Summary
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues See more
Orthologs

Genomic context

See CYSLTR2 in Genome Data Viewer
Location:
13q14.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (48653929..48711226)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49227847..49283498)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370202 Neighboring gene long intergenic non-protein coding RNA 462 Neighboring gene proteasome activator subunit 2 pseudogene 2 Neighboring gene uncharacterized LOC107984559

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galanin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
leukotriene signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cysteinyl leukotriene receptor 2
Names
G-protein coupled receptor GPCR21
G-protein coupled receptor HG57
cysteinyl leukotriene CysLT2 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051649.1 RefSeqGene

    Range
    5219..62516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308465.3NP_001295394.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (I) represents the longest transcript. Variants I to VIII encode the same protein.
    Source sequence(s)
    AL137118, EF141523
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9NS75
    UniProtKB/TrEMBL
    A4ZKH2, Q5KU17
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001308467.3NP_001295396.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295396.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (II) differs in the 5' UTR compared to variant 1. Variants I to VIII encode the same protein.
    Source sequence(s)
    AL137118, EF141524
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9NS75
    UniProtKB/TrEMBL
    A4ZKH2, Q5KU17
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001308468.3NP_001295397.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (III) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
    Source sequence(s)
    AL137118, EF141525
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9NS75
    UniProtKB/TrEMBL
    A4ZKH2, Q5KU17
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. NM_001308469.3NP_001295398.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
    Source sequence(s)
    AL137118, EF141526
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9NS75
    UniProtKB/TrEMBL
    A4ZKH2, Q5KU17
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. NM_001308470.3NP_001295399.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
    Source sequence(s)
    AL137118, EF141529
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9NS75
    UniProtKB/TrEMBL
    A4ZKH2, Q5KU17
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. NM_001308471.3NP_001295400.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
    Source sequence(s)
    AL137118, EF141530
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9NS75
    UniProtKB/TrEMBL
    A4ZKH2, Q5KU17
    Related
    ENSP00000282018.3, ENST00000282018.4
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  7. NM_001308476.3NP_001295405.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001295405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (V) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
    Source sequence(s)
    AL137118, EF141527
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9NS75
    UniProtKB/TrEMBL
    A4ZKH2, Q5KU17
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  8. NM_020377.5NP_065110.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_065110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (VI) differs in the 5' UTR compared to variant I. All variants encode the same protein.
    Source sequence(s)
    AK291739, AL137118
    Consensus CDS
    CCDS9412.1
    UniProtKB/Swiss-Prot
    Q9NS75
    UniProtKB/TrEMBL
    Q5KU17
    Related
    ENSP00000477930.1, ENST00000614739.4
    Conserved Domains (1) summary
    pfam00001
    Location:55305
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    48653929..48711226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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