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PARP11 poly(ADP-ribose) polymerase family member 11 [ Homo sapiens (human) ]

Gene ID: 57097, updated on 3-Feb-2021

Summary

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Official Symbol
PARP11provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 11provided by HGNC
Primary source
HGNC:HGNC:1186
See related
Ensembl:ENSG00000111224 MIM:616706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD11; MIB006; C12orf6
Expression
Ubiquitous expression in prostate (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

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See PARP11 in Genome Data Viewer
Location:
12p13.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (3808861..3873471, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (3918027..3982565, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium release activated channel regulator 2A Neighboring gene RNA, U6 small nuclear 174, pseudogene Neighboring gene uncharacterized LOC107984495 Neighboring gene OTUD4 pseudogene 1 Neighboring gene PARP11 antisense RNA 1 Neighboring gene uncharacterized LOC105369608 Neighboring gene uncharacterized LOC105369611

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice. Meyer-Ficca ML, et al. Biol Reprod, 2015 Mar. PMID 25673562, Free PMC Article
  2. The PARP superfamily. Amé JC, et al. Bioessays, 2004 Aug. PMID 15273990
  3. Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Jia WH, et al. Nat Genet, 2013 Feb. PMID 23263487, Free PMC Article
  4. Family-wide analysis of poly(ADP-ribose) polymerase activity. Vyas S, et al. Nat Commun, 2014 Jul 21. PMID 25043379, Free PMC Article
  5. Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin. Kim J, et al. Am J Cancer Res, 2018. PMID 30323974, Free PMC Article

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Common genetic variation and performance on standardized cognitive tests.
GeneReviews: Not available
Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
GeneReviews: Not available
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp779H0122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
  
mRNA transport IEA
Inferred from Electronic Annotation
more info
  
nuclear envelope organization IEA
Inferred from Electronic Annotation
more info
  
protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
protein mono-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
  
spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
  
nuclear body IDA
Inferred from Direct Assay
more info
  
nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
nuclear pore IEA
Inferred from Electronic Annotation
more info
  
nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP11
Names
ADP-ribosyltransferase diphtheria toxin-like 11
poly [ADP-ribose] polymerase 11
NP_001273450.1
NP_001273451.1
NP_065100.2
XP_011519272.1
XP_011519275.1
XP_016875160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286521.2 → NP_001273450.1  protein mono-ADP-ribosyltransferase PARP11 isoform b

    See identical proteins and their annotated locations for NP_001273450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC006207, AK299372, BX953946
    Consensus CDS
    CCDS66281.1
    UniProtKB/Swiss-Prot
    Q9NR21
    Related
    ENSP00000405385.3, ENST00000447133.7
    Conserved Domains (1) summary
    cd01439
    Location:120 → 256
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

  2. NM_001286522.2 → NP_001273451.1  protein mono-ADP-ribosyltransferase PARP11 isoform b

    See identical proteins and their annotated locations for NP_001273451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and lacks an exon in the 5' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC005842, AC006207, BX953946
    Consensus CDS
    CCDS66281.1
    UniProtKB/Swiss-Prot
    Q9NR21
    Related
    ENSP00000397058.2, ENST00000427057.6
    Conserved Domains (1) summary
    cd01439
    Location:120 → 256
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

  3. NM_020367.6 → NP_065100.2  protein mono-ADP-ribosyltransferase PARP11 isoform a

    See identical proteins and their annotated locations for NP_065100.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC006207, BC017569, BX953946
    Consensus CDS
    CCDS8523.2
    UniProtKB/Swiss-Prot
    Q9NR21
    Related
    ENSP00000228820.4, ENST00000228820.9
    Conserved Domains (2) summary
    smart00678
    Location:34 → 114
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:201 → 337
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

RNA

  1. NR_104461.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC006207, AK314916, BX953946
    Related
    ENST00000458162.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    3808861..3873471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520970.2 → XP_011519272.1  protein mono-ADP-ribosyltransferase PARP11 isoform X1

    See identical proteins and their annotated locations for XP_011519272.1

    UniProtKB/Swiss-Prot
    Q9NR21
    Conserved Domains (2) summary
    smart00678
    Location:27 → 107
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:194 → 330
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

  2. XM_017019671.1 → XP_016875160.1  protein mono-ADP-ribosyltransferase PARP11 isoform X2

    UniProtKB/Swiss-Prot
    Q9NR21
    Conserved Domains (1) summary
    cd01439
    Location:120 → 256
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

  3. XM_011520973.2 → XP_011519275.1  protein mono-ADP-ribosyltransferase PARP11 isoform X1

    See identical proteins and their annotated locations for XP_011519275.1

    UniProtKB/Swiss-Prot
    Q9NR21
    Conserved Domains (2) summary
    smart00678
    Location:27 → 107
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:194 → 330
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NR21.2 GenPept UniProtKB/Swiss-Prot:Q9NR21

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