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PARP11 poly(ADP-ribose) polymerase family member 11 [ Homo sapiens (human) ]

Gene ID: 57097, updated on 3-Feb-2021

Summary

Official Symbol
PARP11provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 11provided by HGNC
Primary source
HGNC:HGNC:1186
See related
Ensembl:ENSG00000111224 MIM:616706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD11; MIB006; C12orf6
Expression
Ubiquitous expression in prostate (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

See PARP11 in Genome Data Viewer
Location:
12p13.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (3808861..3873471, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (3918027..3982565, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium release activated channel regulator 2A Neighboring gene RNA, U6 small nuclear 174, pseudogene Neighboring gene uncharacterized LOC107984495 Neighboring gene OTUD4 pseudogene 1 Neighboring gene PARP11 antisense RNA 1 Neighboring gene uncharacterized LOC105369608 Neighboring gene uncharacterized LOC105369611

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Common genetic variation and performance on standardized cognitive tests.
GeneReviews: Not available
Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
GeneReviews: Not available
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779H0122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope organization IEA
Inferred from Electronic Annotation
more info
 
protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein mono-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP11
Names
ADP-ribosyltransferase diphtheria toxin-like 11
poly [ADP-ribose] polymerase 11
NP_001273450.1
NP_001273451.1
NP_065100.2
XP_011519272.1
XP_011519275.1
XP_016875160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286521.2NP_001273450.1  protein mono-ADP-ribosyltransferase PARP11 isoform b

    See identical proteins and their annotated locations for NP_001273450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC006207, AK299372, BX953946
    Consensus CDS
    CCDS66281.1
    UniProtKB/Swiss-Prot
    Q9NR21
    Related
    ENSP00000405385.3, ENST00000447133.7
    Conserved Domains (1) summary
    cd01439
    Location:120256
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  2. NM_001286522.2NP_001273451.1  protein mono-ADP-ribosyltransferase PARP11 isoform b

    See identical proteins and their annotated locations for NP_001273451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and lacks an exon in the 5' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC005842, AC006207, BX953946
    Consensus CDS
    CCDS66281.1
    UniProtKB/Swiss-Prot
    Q9NR21
    Related
    ENSP00000397058.2, ENST00000427057.6
    Conserved Domains (1) summary
    cd01439
    Location:120256
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  3. NM_020367.6NP_065100.2  protein mono-ADP-ribosyltransferase PARP11 isoform a

    See identical proteins and their annotated locations for NP_065100.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC006207, BC017569, BX953946
    Consensus CDS
    CCDS8523.2
    UniProtKB/Swiss-Prot
    Q9NR21
    Related
    ENSP00000228820.4, ENST00000228820.9
    Conserved Domains (2) summary
    smart00678
    Location:34114
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:201337
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

RNA

  1. NR_104461.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC006207, AK314916, BX953946
    Related
    ENST00000458162.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    3808861..3873471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520970.2XP_011519272.1  protein mono-ADP-ribosyltransferase PARP11 isoform X1

    See identical proteins and their annotated locations for XP_011519272.1

    UniProtKB/Swiss-Prot
    Q9NR21
    Conserved Domains (2) summary
    smart00678
    Location:27107
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:194330
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  2. XM_017019671.1XP_016875160.1  protein mono-ADP-ribosyltransferase PARP11 isoform X2

    UniProtKB/Swiss-Prot
    Q9NR21
    Conserved Domains (1) summary
    cd01439
    Location:120256
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  3. XM_011520973.2XP_011519275.1  protein mono-ADP-ribosyltransferase PARP11 isoform X1

    See identical proteins and their annotated locations for XP_011519275.1

    UniProtKB/Swiss-Prot
    Q9NR21
    Conserved Domains (2) summary
    smart00678
    Location:27107
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:194330
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
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