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PCNP PEST proteolytic signal containing nuclear protein [ Homo sapiens (human) ]

Gene ID: 57092, updated on 24-Nov-2020

Summary

Official Symbol
PCNPprovided by HGNC
Official Full Name
PEST proteolytic signal containing nuclear proteinprovided by HGNC
Primary source
HGNC:HGNC:30023
See related
Ensembl:ENSG00000081154 MIM:615210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 78.0), thyroid (RPKM 65.5) and 25 other tissues See more
Orthologs

Genomic context

See PCNP in Genome Data Viewer
Location:
3q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (101574094..101594465)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101292997..101313281)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr3.3097 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene ribosomal protein S18 pseudogene 5 Neighboring gene ribosomal protein L32 pseudogene 7 Neighboring gene RNA, U6 small nuclear 1256, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781I24156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PEST proteolytic signal-containing nuclear protein
Names
PEST-containing nuclear protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320395.1NP_001307324.1  PEST proteolytic signal-containing nuclear protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB037675, BC013916, BU608892, DA304502
    UniProtKB/Swiss-Prot
    Q8WW12
    Conserved Domains (1) summary
    pfam15473
    Location:23118
    PCNP; PEST, proteolytic signal-containing nuclear protein family
  2. NM_001320397.1NP_001307326.1  PEST proteolytic signal-containing nuclear protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB037675, BU608892, DA304502, DB060329
    UniProtKB/Swiss-Prot
    Q8WW12
    Conserved Domains (1) summary
    pfam15473
    Location:24138
    PCNP; PEST, proteolytic signal-containing nuclear protein family
  3. NM_001320398.1NP_001307327.1  PEST proteolytic signal-containing nuclear protein isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AB037675, BF541732, BU608892, CD696085, DA304502
    UniProtKB/Swiss-Prot
    Q8WW12
    Conserved Domains (1) summary
    pfam15473
    Location:24170
    PCNP; PEST, proteolytic signal-containing nuclear protein family
  4. NM_001320399.1NP_001307328.1  PEST proteolytic signal-containing nuclear protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon and uses an alternate splice junction compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB037675, AC073861, BI596913, BU608892, DA304502
    UniProtKB/Swiss-Prot
    Q8WW12
    Conserved Domains (1) summary
    pfam15473
    Location:20151
    PCNP; PEST, proteolytic signal-containing nuclear protein family
  5. NM_001320400.1NP_001307329.1  PEST proteolytic signal-containing nuclear protein isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (f) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB037675, AC073861, BF244508, BU608892, DA304502
    UniProtKB/Swiss-Prot
    Q8WW12
    Conserved Domains (1) summary
    pfam15473
    Location:2494
    PCNP; PEST, proteolytic signal-containing nuclear protein family
  6. NM_001320401.1NP_001307330.1  PEST proteolytic signal-containing nuclear protein isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (g) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB037675, BU608892, DA304502, DA710370
    UniProtKB/Swiss-Prot
    Q8WW12
    Conserved Domains (1) summary
    pfam15473
    Location:24146
    PCNP; PEST, proteolytic signal-containing nuclear protein family
  7. NM_020357.3NP_065090.1  PEST proteolytic signal-containing nuclear protein isoform a

    See identical proteins and their annotated locations for NP_065090.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC073861
    Consensus CDS
    CCDS2942.1
    UniProtKB/Swiss-Prot
    Q8WW12
    Related
    ENSP00000265260.3, ENST00000265260.8
    Conserved Domains (1) summary
    pfam15473
    Location:24171
    PCNP; PEST, proteolytic signal-containing nuclear protein family

RNA

  1. NR_135223.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037675, BU608892, DA304502
    Related
    ENST00000460231.5
  2. NR_135224.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AB037675, BU608892, DA304502, DB032930
    Related
    ENST00000469941.5
  3. NR_135225.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037675, AC073861, BU608892, DA304502, DA817951
  4. NR_135226.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses an alternate splice junction and lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037675, BU608892, DA304502, DA821754
  5. NR_135227.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037675, AC073861, BI547939, BU608892, DA304502
  6. NR_135228.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037675, BU608892, DA041324, DA304502
  7. NR_135229.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) lacks an alternate exon and contains another alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037675, AC073861, BI913146, BU608892, DA304502
  8. NR_135230.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037675, BU608892, DA304502, DB481581
  9. NR_135231.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AB037675, BU608892, DA304502, HY051831
  10. NR_135232.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) contains an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB037675, AC073861, BU608892, CN482876, DA304502

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    101574094..101594465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006922.1XP_016862411.1  PEST proteolytic signal-containing nuclear protein isoform X1

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