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SLC17A6 solute carrier family 17 member 6 [ Homo sapiens (human) ]

Gene ID: 57084, updated on 23-Nov-2021

Summary

Official Symbol
SLC17A6provided by HGNC
Official Full Name
solute carrier family 17 member 6provided by HGNC
Primary source
HGNC:HGNC:16703
See related
Ensembl:ENSG00000091664 MIM:607563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNPI; VGLUT2
Expression
Restricted expression toward brain (RPKM 2.7) See more
Orthologs
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Genomic context

See SLC17A6 in Genome Data Viewer
Location:
11p14.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (22338381..22379503)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (22359927..22401049)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723370 Neighboring gene uncharacterized LOC105376587 Neighboring gene anoctamin 5 Neighboring gene long intergenic non-protein coding RNA 1495 Neighboring gene uncharacterized LOC105376589 Neighboring gene uncharacterized LOC105376588

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamate transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables neurotransmitter transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hyaloid vascular plexus regression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ion transport TAS
Traceable Author Statement
more info
 
involved_in neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter loading into synaptic vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse structure or activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in excitatory synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vesicular glutamate transporter 2
Names
differentiation-associated BNPI
differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
differentiation-associated Na-dependent inorganic phosphate cotransporter
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
solute carrier family 17 (vesicular glutamate transporter), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020346.3NP_065079.1  vesicular glutamate transporter 2

    See identical proteins and their annotated locations for NP_065079.1

    Status: VALIDATED

    Source sequence(s)
    AB032435, BQ185289, BQ188116, CK823303, DA392769
    Consensus CDS
    CCDS7856.1
    UniProtKB/Swiss-Prot
    Q9P2U8
    Related
    ENSP00000263160.3, ENST00000263160.4
    Conserved Domains (1) summary
    cd17382
    Location:74498
    MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    22338381..22379503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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