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DDX24 DEAD-box helicase 24 [ Homo sapiens (human) ]

Gene ID: 57062, updated on 4-Nov-2018

Summary

Official Symbol
DDX24provided by HGNC
Official Full Name
DEAD-box helicase 24provided by HGNC
Primary source
HGNC:HGNC:13266
See related
Ensembl:ENSG00000089737 MIM:606181; Vega:OTTHUMG00000171301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 90.5), adrenal (RPKM 75.8) and 25 other tissues See more
Orthologs

Genomic context

See DDX24 in Genome Data Viewer
Location:
14q32.12
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (94050922..94081212, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94517268..94547558, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 197 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene interferon alpha inducible protein 27 like 1 Neighboring gene interferon alpha inducible protein 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 (DDX24), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
rev Decreased viral RNA packaging as a result of DDX24-knockdown is observed only in the context of Rev/RRE-dependent but not CTE (constitutive transport element)-mediated nuclear export of viral RNA PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA helicase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX24
Names
DEAD (Asp-Glu-Ala-Asp) box helicase 24
DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
DEAD box protein 24
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24
S. cerevisiae CHL1-like helicase
NP_065147.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020414.3NP_065147.1  ATP-dependent RNA helicase DDX24

    See identical proteins and their annotated locations for NP_065147.1

    Status: REVIEWED

    Source sequence(s)
    AF214731
    Consensus CDS
    CCDS9918.1
    UniProtKB/Swiss-Prot
    Q9GZR7
    Related
    ENSP00000481495.1, OTTHUMP00000245764, ENST00000621632.4, OTTHUMT00000412861
    Conserved Domains (3) summary
    COG0513
    Location:191783
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:573681
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:194511
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    94050922..94081212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1165484..1195774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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