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wdtc1 WD and tetratricopeptide repeats 1 [ Danio rerio (zebrafish) ]

Gene ID: 570606, updated on 4-Jan-2025

Summary

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Official Symbol
wdtc1provided by ZNC
Official Full Name
WD and tetratricopeptide repeats 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3224
See related
Ensembl:ENSDARG00000059760 AllianceGenome:ZFIN:ZDB-GENE-030131-3224
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc31b01; wu:fc31b01; zgc:194983
Summary
Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human WDTC1 (WD and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See wdtc1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54948244..54971446, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (55239744..55263417, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene trophoblast glycoprotein 1a Neighboring gene transmembrane protein 222a Neighboring gene uncharacterized LOC101883215 Neighboring gene uncharacterized LOC137488001

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Severe Coal Tar Sealcoat Runoff Toxicity to Fish Is Prevented by Bioretention Filtration. McIntyre JK, et al. Environ Sci Technol, 2016 Feb 2. PMID 26654684
  2. Confirmation of Stormwater Bioretention Treatment Effectiveness Using Molecular Indicators of Cardiovascular Toxicity in Developing Fish. McIntyre JK, et al. Environ Sci Technol, 2016 Feb 2. PMID 26727247
  3. Parental transgenerational epigenetic inheritance related to dietary crude oil exposure in Danio rerio. Bautista NM, et al. J Exp Biol, 2020 Aug 20. PMID 32620709
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in negative regulation of fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WD and tetratricopeptide repeats protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130606.1 → NP_001124078.1  WD and tetratricopeptide repeats protein 1

    See identical proteins and their annotated locations for NP_001124078.1

    Status: PROVISIONAL

    Source sequence(s)
    BC163463
    UniProtKB/TrEMBL
    A0A8M1NI65, B3DJF2
    Related
    ENSDARP00000099567.1, ENSDART00000113358.4
    Conserved Domains (7) summary
    COG2319
    Location:48 → 324
    WD40; WD40 repeat [General function prediction only]
    sd00006
    Location:365 → 389
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:395 → 431
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:365 → 429
    TPR_11; TPR repeat
    pfam13432
    Location:401 → 466
    TPR_16; Tetratricopeptide repeat
    sd00039
    Location:57 → 93
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:45 → 169
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    54948244..54971446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214001.1 → XP_068070102.1  WD and tetratricopeptide repeats protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1NI65, B3DJF2

  2. XM_005169770.5 → XP_005169827.1  WD and tetratricopeptide repeats protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BH50
    Conserved Domains (7) summary
    COG2319
    Location:48 → 324
    WD40; WD40 repeat [General function prediction only]
    sd00006
    Location:364 → 388
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:394 → 430
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:364 → 428
    TPR_11; TPR repeat
    pfam13432
    Location:400 → 465
    TPR_16; Tetratricopeptide repeat
    sd00039
    Location:57 → 93
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:45 → 169
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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