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TWSG1 twisted gastrulation BMP signaling modulator 1 [ Homo sapiens (human) ]

Gene ID: 57045, updated on 1-Aug-2020

Summary

Official Symbol
TWSG1provided by HGNC
Official Full Name
twisted gastrulation BMP signaling modulator 1provided by HGNC
Primary source
HGNC:HGNC:12429
See related
Ensembl:ENSG00000128791 MIM:605049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG
Expression
Ubiquitous expression in endometrium (RPKM 35.8), gall bladder (RPKM 26.4) and 24 other tissues See more
Orthologs

Genomic context

See TWSG1 in Genome Data Viewer
Location:
18p11.22
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (9334773..9402420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (9334765..9402424)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 12 Neighboring gene uncharacterized LOC107985188 Neighboring gene uncharacterized LOC102724397 Neighboring gene uncharacterized LOC105371980 Neighboring gene ralA binding protein 1 Neighboring gene iroquois homeobox 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of CD4-positive, alpha-beta T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
twisted gastrulation protein homolog 1
Names
twisted gastrulation homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020648.6NP_065699.1  twisted gastrulation protein homolog 1 precursor

    See identical proteins and their annotated locations for NP_065699.1

    Status: VALIDATED

    Source sequence(s)
    AP001033
    Consensus CDS
    CCDS11844.1
    UniProtKB/Swiss-Prot
    Q9GZX9
    Related
    ENSP00000262120.5, ENST00000262120.10
    Conserved Domains (1) summary
    pfam04668
    Location:88222
    Tsg; Twisted gastrulation (Tsg) protein conserved region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    9334773..9402420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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