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SLC17A7 solute carrier family 17 member 7 [ Homo sapiens (human) ]

Gene ID: 57030, updated on 17-Apr-2020

Summary

Official Symbol
SLC17A7provided by HGNC
Official Full Name
solute carrier family 17 member 7provided by HGNC
Primary source
HGNC:HGNC:16704
See related
Ensembl:ENSG00000104888 MIM:605208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BNPI; VGLUT1
Summary
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 231.7) See more
Orthologs

Genomic context

See SLC17A7 in Genome Data Viewer
Location:
19q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49429401..49441527, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49932655..49945617, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene parathyroid hormone 2 Neighboring gene golgi associated olfactory signaling regulator Neighboring gene PIH1 domain containing 1 Neighboring gene aldehyde dehydrogenase 16 family member A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-glutamate transmembrane transporter activity TAS
Traceable Author Statement
more info
 
extracellularly glutamate-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:inorganic phosphate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium:phosphate symporter activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-glutamate import IEA
Inferred from Electronic Annotation
more info
 
L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IEA
Inferred from Electronic Annotation
more info
 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
glutamate secretion TAS
Traceable Author Statement
more info
 
ion transport TAS
Traceable Author Statement
more info
 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
neural retina development IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphate ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of synapse structure or activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
sequestering of neurotransmitter IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle lumen acidification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cerebellar mossy fiber IEA
Inferred from Electronic Annotation
more info
 
clathrin-sculpted glutamate transport vesicle membrane TAS
Traceable Author Statement
more info
 
excitatory synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vesicular glutamate transporter 1
Names
brain-specific Na(+)-dependent inorganic phosphate cotransporter
brain-specific Na-dependent inorganic phosphate cotransporter
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
solute carrier family 17 (vesicular glutamate transporter), member 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020309.4NP_064705.1  vesicular glutamate transporter 1

    See identical proteins and their annotated locations for NP_064705.1

    Status: REVIEWED

    Source sequence(s)
    AB032436, AC010619, BC059379, BQ636968, BU732143
    Consensus CDS
    CCDS12764.1
    UniProtKB/Swiss-Prot
    Q9P2U7
    Related
    ENSP00000221485.2, ENST00000221485.8
    Conserved Domains (1) summary
    cd17382
    Location:66490
    MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49429401..49441527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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