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ryr1b ryanodine receptor 1b (skeletal) [ Danio rerio (zebrafish) ]

Gene ID: 570245, updated on 11-Apr-2024

Summary

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Official Symbol
ryr1bprovided by ZNC
Official Full Name
ryanodine receptor 1b (skeletal)provided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-417
See related
Ensembl:ENSDARG00000023797 AllianceGenome:ZFIN:ZDB-GENE-070705-417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ryrab; im:7137738; si:dkey-250i19.1
Summary
Enables ryanodine-sensitive calcium-release channel activity. Involved in skeletal muscle fiber development and smoothened signaling pathway. Acts upstream of or within cellular response to oxidative stress; larval locomotory behavior; and twitch skeletal muscle contraction. Predicted to be located in membrane and sarcoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be part of calcium channel complex. Predicted to be active in several cellular components, including Z disc; endoplasmic reticulum; and sarcolemma. Is expressed in adaxial cell; heart; skeletal muscle cell; trunk; and trunk musculature. Human ortholog(s) of this gene implicated in central core disease; malignant hyperthermia; and multiminicore disease. Orthologous to human RYR1 (ryanodine receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 18
Exon count:
109
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (35489483..35736799, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (35514635..35755893, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene actin maturation protease Neighboring gene inositol-trisphosphate 3-kinase Cb Neighboring gene RAS guanyl releasing protein 4 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nesfatin-1-like peptide is a negative regulator of cardiovascular functions in zebrafish and goldfish. Sundarrajan L, et al. Gen Comp Endocrinol, 2021 Nov 1. PMID 34453930
  2. Ultrasonography reveals in vivo dose-dependent inhibition of end systolic and diastolic volumes, heart rate and cardiac output by nesfatin-1 in zebrafish. Nair N, et al. Gen Comp Endocrinol, 2016 Aug 1. PMID 26892993
  3. Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle. Perni S, et al. J Gen Physiol, 2015 Mar. PMID 25667412, Free PMC Article
  4. Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy. Dowling JJ, et al. Brain, 2012 Apr. PMID 22418739, Free PMC Article
  5. Developmental transition of touch response from slow muscle-mediated coilings to fast muscle-mediated burst swimming in zebrafish. Naganawa Y, et al. Dev Biol, 2011 Jul 15. PMID 21554867

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ryanodine-sensitive calcium-release channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fast-twitch skeletal muscle fiber contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within larval locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle fiber development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within slow-twitch skeletal muscle fiber contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in striated muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in smooth endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ryanodine receptor 1; ryanodine receptor 1b
Names
relatively relaxed
ryanodine receptor 1b (fast muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102571.1 → NP_001096041.1  ryanodine receptor 1b

    See identical proteins and their annotated locations for NP_001096041.1

    Status: PROVISIONAL

    Source sequence(s)
    AB247454
    UniProtKB/TrEMBL
    A6P4B8
    Related
    ENSDARP00000032856.9, ENSDART00000036015.9
    Conserved Domains (12) summary
    smart00472
    Location:212 → 266
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:643 → 794
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1074 → 1206
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4803 → 4987
    Ion_trans; Ion transport protein
    pfam01365
    Location:444 → 632
    RYDR_ITPR; RIH domain
    pfam02026
    Location:2757 → 2847
    RyR; RyR domain
    pfam02815
    Location:213 → 392
    MIR; MIR domain
    pfam06459
    Location:4400 → 4708
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3896 → 4009
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:9 → 204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam13833
    Location:4100 → 4150
    EF-hand_8; EF-hand domain pair
    cd12879
    Location:1412 → 1551
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    35489483..35736799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017351963.2 → XP_017207452.1  ryanodine receptor 1 isoform X11

    UniProtKB/TrEMBL
    A0A8M6Z1Y9

  2. XM_017351962.2 → XP_017207451.1  ryanodine receptor 1 isoform X10

    UniProtKB/TrEMBL
    A0A8M6YTI9

  3. XM_021467695.1 → XP_021323370.1  ryanodine receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M9PQC8
    Conserved Domains (11) summary
    cd12877
    Location:643 → 794
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1074 → 1206
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1412 → 1551
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4829 → 5013
    Ion_trans; Ion transport protein
    pfam01365
    Location:444 → 635
    RYDR_ITPR; RIH domain
    pfam02026
    Location:851 → 941
    RyR; RyR domain
    pfam02815
    Location:213 → 392
    MIR; MIR domain
    pfam06459
    Location:4426 → 4734
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3902 → 4015
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:4126 → 4176
    EF-hand_8; EF-hand domain pair
    cl19745
    Location:9 → 204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  4. XM_017351961.2 → XP_017207450.1  ryanodine receptor 1 isoform X9

    UniProtKB/TrEMBL
    A0A8M6Z2L8

  5. XM_017351959.2 → XP_017207448.1  ryanodine receptor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M6YU63

  6. XM_017351958.2 → XP_017207447.1  ryanodine receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z1Y4

  7. XM_021467696.1 → XP_021323371.1  ryanodine receptor 1 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PM90
    Conserved Domains (11) summary
    cd12877
    Location:650 → 801
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1081 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1419 → 1558
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4824 → 5008
    Ion_trans; Ion transport protein
    pfam01365
    Location:451 → 642
    RYDR_ITPR; RIH domain
    pfam02026
    Location:858 → 948
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4421 → 4729
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3897 → 4010
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:9 → 211
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam13833
    Location:4121 → 4171
    EF-hand_8; EF-hand domain pair

  8. XM_021467694.1 → XP_021323369.1  ryanodine receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PFJ3
    Conserved Domains (11) summary
    cd12877
    Location:650 → 801
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1081 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1419 → 1558
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4830 → 5014
    Ion_trans; Ion transport protein
    pfam01365
    Location:451 → 642
    RYDR_ITPR; RIH domain
    pfam02026
    Location:858 → 948
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4427 → 4735
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3903 → 4016
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:9 → 211
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam13833
    Location:4127 → 4177
    EF-hand_8; EF-hand domain pair

  9. XM_021467693.1 → XP_021323368.1  ryanodine receptor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PA63
    Conserved Domains (11) summary
    cd12877
    Location:650 → 801
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1081 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1419 → 1558
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4830 → 5014
    Ion_trans; Ion transport protein
    pfam01365
    Location:451 → 642
    RYDR_ITPR; RIH domain
    pfam02026
    Location:858 → 948
    RyR; RyR domain
    pfam02815
    Location:220 → 399
    MIR; MIR domain
    pfam06459
    Location:4427 → 4735
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3903 → 4016
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:9 → 211
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    pfam13833
    Location:4127 → 4177
    EF-hand_8; EF-hand domain pair

  10. XM_017351960.2 → XP_017207449.1  ryanodine receptor 1 isoform X8

    UniProtKB/TrEMBL
    A0A8M6YVZ9

  11. XM_017351957.2 → XP_017207446.1  ryanodine receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YTI2
Nucleotide Protein Strain
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