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VPS35L VPS35 endosomal protein sorting factor like [ Homo sapiens (human) ]

Gene ID: 57020, updated on 26-Oct-2022

Summary

Official Symbol
VPS35Lprovided by HGNC
Official Full Name
VPS35 endosomal protein sorting factor likeprovided by HGNC
Primary source
HGNC:HGNC:24641
See related
Ensembl:ENSG00000103544 MIM:618981; AllianceGenome:HGNC:24641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EC97; RTSC3; C16orf62
Summary
Involved in Golgi to plasma membrane transport and endocytic recycling. Located in endosome. Implicated in Ritscher-Schinzel syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 13.6), brain (RPKM 13.2) and 25 other tissues See more
Orthologs
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Genomic context

See VPS35L in Genome Data Viewer
Location:
16p12.3
Exon count:
32
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (19555703..19701163)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (19486575..19631965)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (19567025..19712485)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene centriolar coiled-coil protein 110 Neighboring gene lysine rich nucleolar protein 1 Neighboring gene IQ motif containing K Neighboring gene uncharacterized LOC105371115

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21040, MGC16824, DKFZp313M0539, DKFZp434B0212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
VPS35 endosomal protein-sorting factor-like
Names
UPF0505 protein C16orf62
esophageal cancer associated protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300743.3NP_001287672.2  VPS35 endosomal protein-sorting factor-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC002550, AC012621, AK095078
    Consensus CDS
    CCDS73840.1
    Related
    ENSP00000442468.1, ENST00000542263.5
  2. NM_001365293.2NP_001352222.1  VPS35 endosomal protein-sorting factor-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC002550, AC012621
  3. NM_001365294.2NP_001352223.1  VPS35 endosomal protein-sorting factor-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC002550, AC012621
  4. NM_001365295.2NP_001352224.1  VPS35 endosomal protein-sorting factor-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC002550, AC012621
    Related
    ENSP00000457973.1, ENST00000543152.5
  5. NM_020314.7NP_064710.5  VPS35 endosomal protein-sorting factor-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC002550, AK290286, AL136744, BP219237, DA452318
    Consensus CDS
    CCDS32397.3
    UniProtKB/Swiss-Prot
    Q9H7C8
    Related
    ENSP00000395973.3, ENST00000417362.7

RNA

  1. NR_158160.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002550, AC012621
  2. NR_158161.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002550, AC012621

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    19555703..19701163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    19486575..19631965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)