Format

Send to:

Choose Destination

AKR1B10 aldo-keto reductase family 1 member B10 [ Homo sapiens (human) ]

Gene ID: 57016, updated on 3-Jun-2018
Official Symbol
AKR1B10provided by HGNC
Official Full Name
aldo-keto reductase family 1 member B10provided by HGNC
Primary source
HGNC:HGNC:382
See related
Ensembl:ENSG00000198074 MIM:604707; Vega:OTTHUMG00000155356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 190.1), stomach (RPKM 138.2) and 4 other tissues See more
Orthologs
See AKR1B10 in Genome Data Viewer
Location:
7q33
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (134527592..134541414)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134212344..134226166)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1 member B Neighboring gene endogenous retrovirus group 3 member 1 pseudogene Neighboring gene uncharacterized LOC105375520 Neighboring gene aldo-keto reductase family 1 member B15 Neighboring gene bisphosphoglycerate mutase

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC14103

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alcohol dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aldo-keto reductase (NADP) activity TAS
Traceable Author Statement
more info
PubMed 
geranylgeranyl reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
indanol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinal dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
daunorubicin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
doxorubicin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
farnesol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
aldo-keto reductase family 1 member B10
Names
ARP
SI reductase
aldo-keto reductase family 1, member B10 (aldose reductase)
aldo-keto reductase family 1, member B11 (aldose reductase-like)
aldose reductase-like 1
aldose reductase-like peptide
aldose reductase-related protein
hARP
small intestine reductase
NP_064695.3
XP_011514718.1
XP_011514719.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020299.4NP_064695.3  aldo-keto reductase family 1 member B10

    See identical proteins and their annotated locations for NP_064695.3

    Status: REVIEWED

    Source sequence(s)
    AF052577, AF524864, BC008837, BM975664
    Consensus CDS
    CCDS5832.1
    UniProtKB/Swiss-Prot
    O60218
    Related
    ENSP00000352584.4, OTTHUMP00000207788, ENST00000359579.4, OTTHUMT00000339615
    Conserved Domains (2) summary
    COG0656
    Location:1297
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16289
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    134527592..134541414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516417.2XP_011514719.1  aldo-keto reductase family 1 member B10 isoform X2

    Conserved Domains (2) summary
    COG0656
    Location:1120
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16113
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  2. XM_011516416.1XP_011514718.1  aldo-keto reductase family 1 member B10 isoform X1

    Conserved Domains (2) summary
    COG0656
    Location:1258
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16250
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RNA

  1. XR_927491.1 RNA Sequence

Support Center