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AKR1B10 aldo-keto reductase family 1 member B10 [ Homo sapiens (human) ]

Gene ID: 57016, updated on 16-Aug-2021

Summary

Official Symbol
AKR1B10provided by HGNC
Official Full Name
aldo-keto reductase family 1 member B10provided by HGNC
Primary source
HGNC:HGNC:382
See related
Ensembl:ENSG00000198074 MIM:604707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 190.1), stomach (RPKM 138.2) and 4 other tissues See more
Orthologs
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Genomic context

See AKR1B10 in Genome Data Viewer
Location:
7q33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (134527567..134541412)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134212319..134226164)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1 member B Neighboring gene endogenous retrovirus group 3 member 1 pseudogene Neighboring gene uncharacterized LOC105375520 Neighboring gene aldo-keto reductase family 1 member B15 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4787

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14103

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aldo-keto reductase family 1 member B10
Names
ARP
SI reductase
aldo-keto reductase family 1, member B10 (aldose reductase)
aldo-keto reductase family 1, member B11 (aldose reductase-like)
aldose reductase-like 1
aldose reductase-like peptide
aldose reductase-related protein
hARP
small intestine reductase
NP_064695.3
XP_011514718.1
XP_011514719.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020299.5NP_064695.3  aldo-keto reductase family 1 member B10

    See identical proteins and their annotated locations for NP_064695.3

    Status: REVIEWED

    Source sequence(s)
    AC078847, AF052577, AF524864, BC008837, BM975664
    Consensus CDS
    CCDS5832.1
    UniProtKB/Swiss-Prot
    O60218
    Related
    ENSP00000352584.4, ENST00000359579.5
    Conserved Domains (1) summary
    cd19107
    Location:10316
    AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    134527567..134541412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516417.2XP_011514719.1  aldo-keto reductase family 1 member B10 isoform X2

    Conserved Domains (2) summary
    COG0656
    Location:1120
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16113
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  2. XM_011516416.1XP_011514718.1  aldo-keto reductase family 1 member B10 isoform X1

    Conserved Domains (2) summary
    COG0656
    Location:1258
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16250
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RNA

  1. XR_927491.1 RNA Sequence

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