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CTNNBIP1 catenin beta interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 56998, updated on 5-Mar-2024

Summary

Official Symbol
CTNNBIP1provided by HGNC
Official Full Name
catenin beta interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:16913
See related
Ensembl:ENSG00000178585 MIM:607758; AllianceGenome:HGNC:16913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICAT
Summary
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 77.0), esophagus (RPKM 25.4) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CTNNBIP1 in Genome Data Viewer
Location:
1p36.22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9848276..9910269, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9391187..9453193, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9908334..9970327, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene uncharacterized LOC124903839 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:9778914-9780113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9780296-9781272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9781273-9782247 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9785121-9785329 Neighboring gene calsyntenin 1 Neighboring gene MPRA-validated peak58 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9846382-9846882 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9848516-9849304 Neighboring gene Sharpr-MPRA regulatory region 8161 Neighboring gene mitotic spindle organizing protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9883897-9884613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 137 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9895719-9896320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9896321-9896920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9902151-9902692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9902693-9903232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9903774-9904313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9908375-9908876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 138 Neighboring gene uncharacterized LOC105376717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9911316-9912116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9919701-9920595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9931412-9932340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9932341-9933268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 236 Neighboring gene uncharacterized LOC124903838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9943986-9944775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9946851-9947439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9960261-9960762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9970922-9971595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9971596-9972268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9987872-9988381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9990871-9991370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9998882-9999382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9999383-9999883 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:10002582-10003781 Neighboring gene leucine zipper and CTNNBIP1 domain containing Neighboring gene RN7SK pseudogene 269 Neighboring gene nicotinamide nucleotide adenylyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC15093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables armadillo repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription initiation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vascular permeability involved in acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of beta-catenin-ICAT complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-catenin-interacting protein 1
Names
beta-catenin-interacting protein ICAT
inhibitor of beta-catenin and Tcf-4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029165.1 RefSeqGene

    Range
    4990..66983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012329.2NP_001012329.1  beta-catenin-interacting protein 1

    See identical proteins and their annotated locations for NP_001012329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL357140, CB995652
    Consensus CDS
    CCDS106.1
    UniProtKB/Swiss-Prot
    Q5T4V2, Q9NSA3
    Related
    ENSP00000383696.3, ENST00000400904.7
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT
  2. NM_020248.3NP_064633.1  beta-catenin-interacting protein 1

    See identical proteins and their annotated locations for NP_064633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL357140, BI226022, CB995652
    Consensus CDS
    CCDS106.1
    UniProtKB/Swiss-Prot
    Q5T4V2, Q9NSA3
    Related
    ENSP00000366474.1, ENST00000377263.6
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9848276..9910269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425762.1XP_047281718.1  beta-catenin-interacting protein 1 isoform X1

  2. XM_047425765.1XP_047281721.1  beta-catenin-interacting protein 1 isoform X1

  3. XM_047425763.1XP_047281719.1  beta-catenin-interacting protein 1 isoform X1

  4. XM_047425770.1XP_047281726.1  beta-catenin-interacting protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5T4V2, Q9NSA3
  5. XM_047425766.1XP_047281722.1  beta-catenin-interacting protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    9391187..9453193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337777.1XP_054193752.1  beta-catenin-interacting protein 1 isoform X1

  2. XM_054337779.1XP_054193754.1  beta-catenin-interacting protein 1 isoform X1

  3. XM_054337778.1XP_054193753.1  beta-catenin-interacting protein 1 isoform X1

  4. XM_054337780.1XP_054193755.1  beta-catenin-interacting protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5T4V2, Q9NSA3
  5. XM_054337782.1XP_054193757.1  beta-catenin-interacting protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5T4V2, Q9NSA3
  6. XM_054337781.1XP_054193756.1  beta-catenin-interacting protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5T4V2, Q9NSA3