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CTNNBIP1 catenin beta interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 56998, updated on 3-Oct-2020

Summary

Official Symbol
CTNNBIP1provided by HGNC
Official Full Name
catenin beta interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:16913
See related
Ensembl:ENSG00000178585 MIM:607758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICAT
Summary
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 77.0), esophagus (RPKM 25.4) and 24 other tissues See more
Orthologs

Genomic context

See CTNNBIP1 in Genome Data Viewer
Location:
1p36.22
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (9848276..9910322, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9908334..9970316, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene PIK3CD antisense RNA 2 Neighboring gene calsyntenin 1 Neighboring gene mitotic spindle organizing protein 1 pseudogene 1 Neighboring gene uncharacterized LOC105376717 Neighboring gene leucine zipper and CTNNBIP1 domain containing Neighboring gene RN7SK pseudogene 269 Neighboring gene nicotinamide nucleotide adenylyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
armadillo repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-catenin-interacting protein 1
Names
beta-catenin-interacting protein ICAT
inhibitor of beta-catenin and Tcf-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029165.1 RefSeqGene

    Range
    4990..66983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012329.2NP_001012329.1  beta-catenin-interacting protein 1

    See identical proteins and their annotated locations for NP_001012329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL357140, CB995652
    Consensus CDS
    CCDS106.1
    UniProtKB/Swiss-Prot
    Q9NSA3
    UniProtKB/TrEMBL
    A0A024R4D7
    Related
    ENSP00000383696.3, ENST00000400904.7
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT
  2. NM_020248.3NP_064633.1  beta-catenin-interacting protein 1

    See identical proteins and their annotated locations for NP_064633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL357140, BI226022, CB995652
    Consensus CDS
    CCDS106.1
    UniProtKB/Swiss-Prot
    Q9NSA3
    UniProtKB/TrEMBL
    A0A024R4D7
    Related
    ENSP00000366474.1, ENST00000377263.6
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    9848276..9910322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001853.2XP_016857342.1  beta-catenin-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NSA3
    UniProtKB/TrEMBL
    A0A024R4D7
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT
  2. XM_017001854.2XP_016857343.1  beta-catenin-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NSA3
    UniProtKB/TrEMBL
    A0A024R4D7
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT
  3. XM_017001855.2XP_016857344.1  beta-catenin-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9NSA3
    UniProtKB/TrEMBL
    A0A024R4D7
    Related
    ENSP00000366468.1, ENST00000377258.5
    Conserved Domains (1) summary
    pfam06384
    Location:179
    ICAT; Beta-catenin-interacting protein ICAT
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