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TOMM22 translocase of outer mitochondrial membrane 22 [ Homo sapiens (human) ]

Gene ID: 56993, updated on 7-Oct-2018

Summary

Official Symbol
TOMM22provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 22provided by HGNC
Primary source
HGNC:HGNC:18002
See related
Ensembl:ENSG00000100216 MIM:607046; Vega:OTTHUMG00000150991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
1C9-2; TOM22; MST065; MSTP065
Summary
The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 24.2), kidney (RPKM 23.3) and 25 other tissues See more
Orthologs

Genomic context

See TOMM22 in Genome Data Viewer
Location:
22q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (38681949..38684760)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39077954..39080765)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227 member A Neighboring gene chibby family member 1, beta catenin antagonist Neighboring gene Josephin domain containing 1 Neighboring gene GTP binding protein 1 Neighboring gene peroxiredoxin 3 pseudogene 1 Neighboring gene Sad1 and UNC84 domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of translocase of outer mitochondrial membrane 22 (TOMM22) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
retropepsin gag-pol HIV-1 PR interacts with mitochondrial proteins VDAC, cytochrome c, TOM22, and Bax in HeLa cells PubMed
gag-pol HIV-1 PR cleaves TOM22 in a dose-dependent manner in HEK293 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitochondrial protein import, organism-specific biosystem (from REACTOME)
    Mitochondrial protein import, organism-specific biosystemA human mitochondrion contains about 1500 proteins, more than 99% of which are encoded in the nucleus, synthesized in the cytosol and imported into the mitochondrion. Proteins are targeted to four lo...
  • Mitophagy, organism-specific biosystem (from REACTOME)
    Mitophagy, organism-specific biosystemMitophagy is a specific form of autophagy where mitochondria are specifically targeted for degradation by autophagolysosomes.. In mammals there are a number of known mechanisms of mitophagy. One insu...
  • Pink/Parkin Mediated Mitophagy, organism-specific biosystem (from REACTOME)
    Pink/Parkin Mediated Mitophagy, organism-specific biosystemThis is the process of selective removal of damaged mitochondria by autophagosomes and subsequent catabolism by lysosomes. In healthy mitochondria, PINK1 is imported to the inner mitochondrial membra...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein import into mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein insertion into mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
PubMed 
protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrial outer membrane translocase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM22 homolog
Names
mitochondrial import receptor Tom22
translocase of outer membrane 22 kDa subunit homolog
translocase of outer mitochondrial membrane 22 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020243.4NP_064628.1  mitochondrial import receptor subunit TOM22 homolog

    See identical proteins and their annotated locations for NP_064628.1

    Status: REVIEWED

    Source sequence(s)
    AA522979, AB041906, BQ961547, CB142641
    Consensus CDS
    CCDS13975.1
    UniProtKB/Swiss-Prot
    Q9NS69
    UniProtKB/TrEMBL
    Q549C5
    Related
    ENSP00000216034.4, OTTHUMP00000198879, ENST00000216034.5, OTTHUMT00000320842

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    38681949..38684760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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