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KIF15 kinesin family member 15 [ Homo sapiens (human) ]

Gene ID: 56992, updated on 6-Aug-2022

Summary

Official Symbol
KIF15provided by HGNC
Official Full Name
kinesin family member 15provided by HGNC
Primary source
HGNC:HGNC:17273
See related
Ensembl:ENSG00000163808 MIM:617569; AllianceGenome:HGNC:17273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLP2; HKLP2; KNSL7; BRDCS2; NY-BR-62
Summary
Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 8.0), bone marrow (RPKM 4.1) and 13 other tissues See more
Orthologs
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Genomic context

See KIF15 in Genome Data Viewer
Location:
3p21.31
Exon count:
40
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44761794..44868687)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44777475..44868975)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44803286..44894748)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 501 Neighboring gene KIAA1143 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 77 Neighboring gene microRNA 564 Neighboring gene transmembrane protein 42 Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene transglutaminase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
BRADDOCK-CAREY SYNDROME 2
MedGen: CN315827 OMIM: 619981 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25667

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of plus-end kinesin complex TAS
Traceable Author Statement
more info
PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin-like protein KIF15
Names
kinesin-like 7
kinesin-like protein 2
kinesin-like protein 7
serologically defined breast cancer antigen NY-BR-62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020242.3NP_064627.1  kinesin-like protein KIF15

    See identical proteins and their annotated locations for NP_064627.1

    Status: VALIDATED

    Source sequence(s)
    AB035898, AK307674, AL832908, DR005852
    Consensus CDS
    CCDS33744.1
    UniProtKB/Swiss-Prot
    Q9H280, Q9NS87
    Related
    ENSP00000324020.4, ENST00000326047.9
    Conserved Domains (5) summary
    smart00129
    Location:26370
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1196
    Location:4901331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01373
    Location:25373
    KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
    pfam12711
    Location:463551
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:12811376
    HMMR_C; Hyaluronan mediated motility receptor C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44761794..44868687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006884.3XP_016862373.1  kinesin-like protein KIF15 isoform X1

  2. XM_011533964.4XP_011532266.1  kinesin-like protein KIF15 isoform X3

    See identical proteins and their annotated locations for XP_011532266.1

    Conserved Domains (5) summary
    smart00129
    Location:26370
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1196
    Location:4901265
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01373
    Location:25373
    KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
    pfam12711
    Location:463551
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:12151310
    HMMR_C; Hyaluronan mediated motility receptor C-terminal
  3. XM_017006885.3XP_016862374.1  kinesin-like protein KIF15 isoform X2

  4. XM_017006887.3XP_016862376.1  kinesin-like protein KIF15 isoform X4

  5. XM_017006889.3XP_016862378.1  kinesin-like protein KIF15 isoform X8

  6. XM_047448602.1XP_047304558.1  kinesin-like protein KIF15 isoform X6

  7. XM_047448603.1XP_047304559.1  kinesin-like protein KIF15 isoform X7

  8. XM_047448601.1XP_047304557.1  kinesin-like protein KIF15 isoform X5

  9. XM_017006890.2XP_016862379.1  kinesin-like protein KIF15 isoform X9

  10. XM_006713264.4XP_006713327.1  kinesin-like protein KIF15 isoform X10

    See identical proteins and their annotated locations for XP_006713327.1

    UniProtKB/TrEMBL
    C9JKA9
    Related
    ENSP00000389982.1, ENST00000425755.5
    Conserved Domains (3) summary
    COG1196
    Location:125901
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12711
    Location:98186
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:9161011
    HMMR_C; Hyaluronan mediated motility receptor C-terminal

RNA

  1. XR_007095708.1 RNA Sequence

    Related
    ENST00000438321.5
  2. XR_007095709.1 RNA Sequence

  3. XR_007095710.1 RNA Sequence

  4. XR_001740214.2 RNA Sequence

  5. XR_001740215.2 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    287144..378606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44777475..44868975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)