Format

Send to:

Choose Destination

KIF15 kinesin family member 15 [ Homo sapiens (human) ]

Gene ID: 56992, updated on 11-Sep-2019

Summary

Official Symbol
KIF15provided by HGNC
Official Full Name
kinesin family member 15provided by HGNC
Primary source
HGNC:HGNC:17273
See related
Ensembl:ENSG00000163808 MIM:617569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLP2; HKLP2; KNSL7; NY-BR-62
Expression
Biased expression in testis (RPKM 8.0), bone marrow (RPKM 4.1) and 13 other tissues See more
Orthologs

Genomic context

See KIF15 in Genome Data Viewer
Location:
3p21.31
Exon count:
40
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44761740..44853274)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44803209..44894748)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 501 Neighboring gene KIAA1143 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 77 Neighboring gene microRNA 564 Neighboring gene transmembrane protein 42 Neighboring gene peptidylprolyl isomerase A pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
    Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25667

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement TAS
Traceable Author Statement
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plus-end kinesin complex TAS
Traceable Author Statement
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin-like protein KIF15
Names
kinesin-like 7
kinesin-like protein 2
kinesin-like protein 7
serologically defined breast cancer antigen NY-BR-62

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020242.3NP_064627.1  kinesin-like protein KIF15

    See identical proteins and their annotated locations for NP_064627.1

    Status: VALIDATED

    Source sequence(s)
    AB035898, AK307674, AL832908, DR005852
    Consensus CDS
    CCDS33744.1
    UniProtKB/Swiss-Prot
    Q9NS87
    Related
    ENSP00000324020.4, ENST00000326047.9
    Conserved Domains (5) summary
    smart00129
    Location:26370
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1196
    Location:4901331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01373
    Location:25373
    KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
    pfam12711
    Location:463551
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:12811376
    HMMR_C; Hyaluronan mediated motility receptor C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    44761740..44853274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006886.2XP_016862375.1  kinesin-like protein KIF15 isoform X4

  2. XM_017006885.2XP_016862374.1  kinesin-like protein KIF15 isoform X2

  3. XM_017006884.2XP_016862373.1  kinesin-like protein KIF15 isoform X1

  4. XM_011533964.3XP_011532266.1  kinesin-like protein KIF15 isoform X3

    See identical proteins and their annotated locations for XP_011532266.1

    Conserved Domains (5) summary
    smart00129
    Location:26370
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1196
    Location:4901265
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01373
    Location:25373
    KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
    pfam12711
    Location:463551
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:12151310
    HMMR_C; Hyaluronan mediated motility receptor C-terminal
  5. XM_017006887.2XP_016862376.1  kinesin-like protein KIF15 isoform X5

  6. XM_017006889.2XP_016862378.1  kinesin-like protein KIF15 isoform X7

  7. XM_017006888.1XP_016862377.1  kinesin-like protein KIF15 isoform X6

  8. XM_017006890.1XP_016862379.1  kinesin-like protein KIF15 isoform X8

  9. XM_006713264.3XP_006713327.1  kinesin-like protein KIF15 isoform X9

    See identical proteins and their annotated locations for XP_006713327.1

    UniProtKB/TrEMBL
    C9JKA9
    Related
    ENSP00000389982.1, ENST00000425755.5
    Conserved Domains (3) summary
    COG1196
    Location:125901
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12711
    Location:98186
    Kinesin-relat_1; Kinesin motor
    pfam15908
    Location:9161011
    HMMR_C; Hyaluronan mediated motility receptor C-terminal

RNA

  1. XR_002959555.1 RNA Sequence

    Related
    ENST00000438321.5
  2. XR_001740214.2 RNA Sequence

  3. XR_001740215.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p13 PATCHES

    Range
    287144..378606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center