Format

Send to:

Choose Destination

CDC42SE2 CDC42 small effector 2 [ Homo sapiens (human) ]

Gene ID: 56990, updated on 12-Aug-2018

Summary

Official Symbol
CDC42SE2provided by HGNC
Official Full Name
CDC42 small effector 2provided by HGNC
Primary source
HGNC:HGNC:18547
See related
Ensembl:ENSG00000158985 Vega:OTTHUMG00000162692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPEC2
Expression
Ubiquitous expression in lymph node (RPKM 52.2), appendix (RPKM 43.6) and 25 other tissues See more
Orthologs

Genomic context

See CDC42SE2 in Genome Data Viewer
Location:
5q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (131264009..131394690)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (130599702..130730383)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene LYR motif containing 7 Neighboring gene uncharacterized LOC105379173 Neighboring gene Rap guanine nucleotide exchange factor 6 Neighboring gene folliculin interacting protein 1 Neighboring gene actin, beta pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21967

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho GTPase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural molecule activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
phagocytic cup IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CDC42 small effector protein 2
Names
non-kinase Cdc42 effector protein SPEC2
small effector of CDC42 protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038702.1NP_001033791.1  CDC42 small effector protein 2

    See identical proteins and their annotated locations for NP_001033791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5'UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI440226, AK025620, BC050430, BC058909, BI522591, CB135092, DA321488
    Consensus CDS
    CCDS34224.1
    UniProtKB/Swiss-Prot
    Q9NRR3
    Related
    ENSP00000378667.1, ENST00000395246.5
    Conserved Domains (1) summary
    cd00132
    Location:2767
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. NM_020240.2NP_064625.1  CDC42 small effector protein 2

    See identical proteins and their annotated locations for NP_064625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI440226, AK025620, BC050430, BC058909, BI460220, CB135092
    Consensus CDS
    CCDS34224.1
    UniProtKB/Swiss-Prot
    Q9NRR3
    Related
    ENSP00000353706.3, OTTHUMP00000222550, ENST00000360515.7, OTTHUMT00000370101
    Conserved Domains (1) summary
    cd00132
    Location:2767
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    131264009..131394690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009649.2XP_016865138.1  CDC42 small effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NRR3
    Conserved Domains (1) summary
    cd00132
    Location:2767
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. XM_017009648.2XP_016865137.1  CDC42 small effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9NRR3
    Related
    ENSP00000427421.1, OTTHUMP00000222551, ENST00000505065.1
    Conserved Domains (1) summary
    cd00132
    Location:2767
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
Support Center