rgs4 regulator of G protein signaling 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rgs4provided by ZNC
Official Full Name: regulator of G protein signaling 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9839
See related: Ensembl:ENSDARG00000070047 AllianceGenome:ZFIN:ZDB-GENE-030131-9839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb436; sb:cb436; wu:fc06d08
Summary: Acts upstream of or within axonogenesis; endocrine pancreas development; and locomotory behavior. Is expressed in several structures, including digestive system; mucus secreting cell; nervous system; pronephric duct; and spinal cord neural tube. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	6	NC_133181.1 (37876511..37916181)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (35362239..35366944)

Chromosome 6 - NC_133181.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rgs4 knockdown also attenuated the level of phosphorylated-Akt1, and injection of constitutively-activated AKT1 rescued the motility defects and axonal phenotypes in the spinal cord but not in the hindbrain and trigeminal neurons.
Title: Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling.
Rgs4 is expressed in endocrine progenitors of both zebrafish and mouse, and its expression in the mouse pancreatic epithelium is strictly dependent upon Ngn3, and loss of function of Rgs4 results in islet fragmentation in both organisms.
Title: G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis.

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General gene information

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Markers

fc93g01.x1 (e-PCR)
- UniSTS:194819

fc06d08.x1 (e-PCR)
- UniSTS:203727

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 4

Names: regulator of G-protein signalling 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001442130.1 → NP_001429059.1 regulator of G-protein signaling 4 isoform 1

Status: VALIDATED

Source sequence(s)

JBMGRA010000006
NM_001442131.1 → NP_001429060.1 regulator of G-protein signaling 4 isoform 1

Status: VALIDATED

Source sequence(s)

JBMGRA010000006
NM_001442132.1 → NP_001429061.1 regulator of G-protein signaling 4 isoform 2

Status: VALIDATED

Source sequence(s)

JBMGRA010000006
NM_001442133.1 → NP_001429062.1 regulator of G-protein signaling 4 isoform 3

Status: VALIDATED

Source sequence(s)

JBMGRA010000006
NM_001442134.1 → NP_001429063.1 regulator of G-protein signaling 4 isoform 4

Status: VALIDATED

Source sequence(s)

JBMGRA010000006
NM_199274.2 → NP_954968.2 regulator of G-protein signaling 4 isoform 1

Status: VALIDATED

Source sequence(s)

JBMGRA010000006

Related

ENSDARP00000093260.3, ENSDART00000102483.5