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DTWD1 DTW domain containing 1 [ Homo sapiens (human) ]

Gene ID: 56986, updated on 5-Aug-2022

Summary

Official Symbol
DTWD1provided by HGNC
Official Full Name
DTW domain containing 1provided by HGNC
Primary source
HGNC:HGNC:30926
See related
Ensembl:ENSG00000104047 AllianceGenome:HGNC:30926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS009
Summary
Enables tRNA-uridine aminocarboxypropyltransferase activity. Involved in tRNA modification. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 2.7), gall bladder (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

See DTWD1 in Genome Data Viewer
Location:
15q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (49621048..49656232)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (47429430..47464635)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (49913245..49948429)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227 member B Neighboring gene fibroblast growth factor 7 Neighboring gene uncharacterized LOC105370811 Neighboring gene ring finger protein, LIM domain interacting pseudogene 3 Neighboring gene uncharacterized LOC102724587 Neighboring gene ATPase phospholipid transporting 8B4 (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111207

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables tRNA-uridine aminocarboxypropyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA-uridine aminocarboxypropyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tRNA-uridine aminocarboxypropyltransferase 1
Names
DTW domain-containing protein 1
x 009 protein
NP_001138427.1
NP_064619.2
XP_011520117.1
XP_016877912.1
XP_016877913.1
XP_016877914.1
XP_016877915.1
XP_047288835.1
XP_047288836.1
XP_047288837.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144955.2NP_001138427.1  tRNA-uridine aminocarboxypropyltransferase 1

    See identical proteins and their annotated locations for NP_001138427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC018927
    Consensus CDS
    CCDS10132.1
    UniProtKB/Swiss-Prot
    Q8N5C7, Q9NRU6
    Related
    ENSP00000385399.3, ENST00000403028.8
    Conserved Domains (1) summary
    pfam03942
    Location:66289
    DTW; DTW domain
  2. NM_020234.6NP_064619.2  tRNA-uridine aminocarboxypropyltransferase 1

    See identical proteins and their annotated locations for NP_064619.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC018927
    Consensus CDS
    CCDS10132.1
    UniProtKB/Swiss-Prot
    Q8N5C7, Q9NRU6
    Related
    ENSP00000251250.6, ENST00000251250.7
    Conserved Domains (1) summary
    pfam03942
    Location:66289
    DTW; DTW domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    49621048..49656232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022426.2XP_016877915.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam03942
    Location:66222
    DTW; DTW domain
  2. XM_047432881.1XP_047288837.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

  3. XM_017022425.2XP_016877914.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam03942
    Location:66222
    DTW; DTW domain
  4. XM_011521815.3XP_011520117.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam03942
    Location:66222
    DTW; DTW domain
  5. XM_047432880.1XP_047288836.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

  6. XM_047432879.1XP_047288835.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

  7. XM_017022424.2XP_016877913.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

  8. XM_017022423.3XP_016877912.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    47429430..47464635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)