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PSMG2 proteasome assembly chaperone 2 [ Homo sapiens (human) ]

Gene ID: 56984, updated on 7-Jun-2020

Summary

Official Symbol
PSMG2provided by HGNC
Official Full Name
proteasome assembly chaperone 2provided by HGNC
Primary source
HGNC:HGNC:24929
See related
Ensembl:ENSG00000128789 MIM:609702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAC2; HCCA3; CLAST3; MDS003; HsT1707; TNFSF5IP1
Expression
Ubiquitous expression in testis (RPKM 46.4), bone marrow (RPKM 28.3) and 25 other tissues See more
Orthologs

Genomic context

See PSMG2 in Genome Data Viewer
Location:
18p11.21
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (12658739..12725740)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12658738..12725739)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371998 Neighboring gene high mobility group box 3 pseudogene 28 Neighboring gene spire type actin nucleation factor 1 Neighboring gene centrosomal protein 76 Neighboring gene long intergenic non-protein coding RNA 1882 Neighboring gene protein tyrosine phosphatase non-receptor type 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular adaptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
chaperone-mediated protein complex assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic spindle assembly checkpoint IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
proteasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteasome assembly chaperone 2
Names
CD40 ligand-activated specific transcript 3
HDCMC29P
HSPC260
PAC-2
hepatocellular carcinoma susceptibility protein
hepatocellular carcinoma-susceptibility protein 3
likely ortholog of mouse CD40 ligand-activated specific transcript 3 (Clast3)
proteasome (prosome, macropain) assembly chaperone 2
proteasome assembling chaperone 2
tumor necrosis factor superfamily member 5-induced protein 1
x 003 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020232.5NP_064617.2  proteasome assembly chaperone 2 isoform 1

    See identical proteins and their annotated locations for NP_064617.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK057005, BC013356, BF668035
    Consensus CDS
    CCDS11862.1
    UniProtKB/Swiss-Prot
    Q969U7
    Related
    ENSP00000325919.6, ENST00000317615.11
    Conserved Domains (1) summary
    pfam09754
    Location:17123
    PAC2; PAC2 family
  2. NM_147163.1NP_671692.1  proteasome assembly chaperone 2 isoform 2

    See identical proteins and their annotated locations for NP_671692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF068295, AK057005, BC013356
    Consensus CDS
    CCDS67440.1
    UniProtKB/Swiss-Prot
    Q969U7
    UniProtKB/TrEMBL
    Q9P1R6
    Related
    ENSP00000476763.1, ENST00000585331.6
    Conserved Domains (1) summary
    pfam09754
    Location:295
    PAC2; PAC2 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    12658739..12725740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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