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grm8b glutamate receptor, metabotropic 8b [ Danio rerio (zebrafish) ]

Gene ID: 569768, updated on 11-Apr-2024

Summary

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Official Symbol
grm8bprovided by ZNC
Official Full Name
glutamate receptor, metabotropic 8bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110421-3
See related
Ensembl:ENSDARG00000076508 AllianceGenome:ZFIN:ZDB-GENE-110421-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-56n2.1
Summary
Predicted to enable group III metabotropic glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain and sensory system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 25
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (26921802..27237316)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (26478619..26794207)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene si:dkey-42p14.3 Neighboring gene zinc finger protein 800a Neighboring gene uncharacterized LOC110438395 Neighboring gene uncharacterized LOC103909868 Neighboring gene protection of telomeres 1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes Grm8a and Grm8b Display Distinct Behavioral Phenotypes in Zebrafish Larvae (Danio rerio). Lüffe TM, et al. Front Mol Neurosci, 2022. PMID 35769333, Free PMC Article
  2. Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). Haug MF, et al. J Comp Neurol, 2013 May 1. PMID 23047810
  3. Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. Huang YY, et al. PLoS One, 2012. PMID 22523578, Free PMC Article
  4. Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Pandey S, et al. Curr Biol, 2018 Apr 2. PMID 29576475, Free PMC Article
  5. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables group III metabotropic glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate receptor, metabotropic 8b
Names
grm8a
metabotropic glutamate receptor 8b
mglur8b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287539.1 → NP_001274468.1  glutamate receptor, metabotropic 8b precursor

    See identical proteins and their annotated locations for NP_001274468.1

    Status: PROVISIONAL

    Source sequence(s)
    KF234093
    UniProtKB/TrEMBL
    A0A2R8QSR1, E7F4Z5
    Related
    ENSDARP00000156406.1, ENSDART00000187364.1
    Conserved Domains (4) summary
    pfam00003
    Location:594 → 839
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:73 → 477
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:512 → 558
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:43 → 503
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    26921802..27237316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001922020.5 → XP_001922055.2  glutamate receptor, metabotropic 8b isoform X1

    See identical proteins and their annotated locations for XP_001922055.2

    UniProtKB/TrEMBL
    A0A2R8QSR1, E7F4Z5
    Related
    ENSDARP00000127806.1, ENSDART00000155949.2
    Conserved Domains (4) summary
    pfam00003
    Location:594 → 839
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:73 → 477
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:512 → 558
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:43 → 503
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
Nucleotide Protein Strain
Heading Accession and Version

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