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PYY peptide YY [ Homo sapiens (human) ]

Gene ID: 5697, updated on 6-Sep-2021

Summary

Official Symbol
PYYprovided by HGNC
Official Full Name
peptide YYprovided by HGNC
Primary source
HGNC:HGNC:9748
See related
Ensembl:ENSG00000131096 MIM:600781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PYY1; PYY-I
Summary
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
Expression
Biased expression in colon (RPKM 24.9) and small intestine (RPKM 4.4) See more
Orthologs
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Genomic context

See PYY in Genome Data Viewer
Location:
17q21.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43952733..44004445, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42030101..42081813, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1976 Neighboring gene pancreatic polypeptide Neighboring gene N-acetylglutamate synthase Neighboring gene transmembrane protein 101

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide Y receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intestinal epithelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
peptide YY
Names
peptide tyrosine tyrosine
prepro-PYY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023338.1 RefSeqGene

    Range
    5001..56737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394028.1NP_001380957.1  peptide YY isoform 1 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC007993
    Conserved Domains (1) summary
    smart00309
    Location:2964
    PAH; Pancreatic hormones / neuropeptide F / peptide YY family
  2. NM_001394029.1NP_001380958.1  peptide YY isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007993
    Conserved Domains (1) summary
    smart00309
    Location:2964
    PAH; Pancreatic hormones / neuropeptide F / peptide YY family
  3. NM_004160.6NP_004151.4  peptide YY isoform 1 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC007993, AC023855
    Consensus CDS
    CCDS32662.1
    Related
    ENSP00000353198.1, ENST00000360085.6
    Conserved Domains (1) summary
    smart00309
    Location:2964
    PAH; Pancreatic hormones / neuropeptide F / peptide YY family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43952733..44004445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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