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PARP6 poly(ADP-ribose) polymerase family member 6 [ Homo sapiens (human) ]

Gene ID: 56965, updated on 8-Dec-2022

Summary

Official Symbol
PARP6provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 6provided by HGNC
Primary source
HGNC:HGNC:26921
See related
Ensembl:ENSG00000137817 MIM:619439; AllianceGenome:HGNC:26921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD17; pART17; PARP-6-C; PARP-6-B1
Summary
Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 26.3), thyroid (RPKM 13.7) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See PARP6 in Genome Data Viewer
Location:
15q23
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72241181..72272554, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70057855..70089224, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72533522..72564895, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:72529434-72530633 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:72529434-72530633 Neighboring gene uncharacterized LOC105370887 Neighboring gene CUGBP Elav-like family member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131971

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+- protein-aspartate ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+- protein-cysteine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP6
Names
ADP-ribosyltransferase diphtheria toxin-like 17
MIEREN, class I
MIEREN, class II
PARP-6
poly [ADP-ribose] polymerase 6
NP_001310444.1
NP_001310445.1
NP_001310448.1
NP_001310450.1
NP_001310451.1
NP_001310452.1
NP_001310453.1
NP_001310454.1
NP_001310455.1
NP_001310457.1
NP_001310459.1
NP_001310460.1
NP_001310461.1
NP_064599.2
XP_011520107.1
XP_047288829.1
XP_047288830.1
XP_047288831.1
XP_047288832.1
XP_047288833.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323515.2NP_001310444.1  protein mono-ADP-ribosyltransferase PARP6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Related
    ENSP00000455815.1, ENST00000567974.5
    Conserved Domains (1) summary
    cd01341
    Location:451575
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  2. NM_001323516.2NP_001310445.1  protein mono-ADP-ribosyltransferase PARP6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:451575
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  3. NM_001323519.2NP_001310448.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:450574
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  4. NM_001323521.2NP_001310450.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:450574
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  5. NM_001323522.2NP_001310451.1  protein mono-ADP-ribosyltransferase PARP6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Consensus CDS
    CCDS10241.2
    UniProtKB/Swiss-Prot
    Q2NL67, Q9UFG4
    UniProtKB/TrEMBL
    A0A024R5Z4
    Conserved Domains (1) summary
    cd01341
    Location:470594
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  6. NM_001323523.2NP_001310452.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:450574
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  7. NM_001323524.2NP_001310453.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:450574
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  8. NM_001323525.2NP_001310454.1  protein mono-ADP-ribosyltransferase PARP6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:471595
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  9. NM_001323526.2NP_001310455.1  protein mono-ADP-ribosyltransferase PARP6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:450574
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  10. NM_001323528.2NP_001310457.1  protein mono-ADP-ribosyltransferase PARP6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:471595
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  11. NM_001323530.2NP_001310459.1  protein mono-ADP-ribosyltransferase PARP6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:451575
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  12. NM_001323531.2NP_001310460.1  protein mono-ADP-ribosyltransferase PARP6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Conserved Domains (1) summary
    cd01341
    Location:471595
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  13. NM_001323532.2NP_001310461.1  protein mono-ADP-ribosyltransferase PARP6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Consensus CDS
    CCDS10241.2
    UniProtKB/Swiss-Prot
    Q2NL67, Q9UFG4
    UniProtKB/TrEMBL
    A0A024R5Z4
    Related
    ENSP00000456348.1, ENST00000569795.6
    Conserved Domains (1) summary
    cd01341
    Location:470594
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  14. NM_020214.4NP_064599.2  protein mono-ADP-ribosyltransferase PARP6 isoform 1

    See identical proteins and their annotated locations for NP_064599.2

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Consensus CDS
    CCDS10241.2
    UniProtKB/Swiss-Prot
    Q2NL67, Q9UFG4
    UniProtKB/TrEMBL
    A0A024R5Z4
    Related
    ENSP00000287196.9, ENST00000287196.13
    Conserved Domains (1) summary
    cd01341
    Location:470594
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

RNA

  1. NR_136594.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  2. NR_136596.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  3. NR_136599.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  4. NR_136603.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  5. NR_136604.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  6. NR_136605.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
    Related
    ENST00000567440.5
  7. NR_136606.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  8. NR_136607.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  9. NR_136608.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  10. NR_136609.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  11. NR_136610.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690
  12. NR_136611.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009690

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    72241181..72272554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432874.1XP_047288830.1  protein mono-ADP-ribosyltransferase PARP6 isoform X2

    UniProtKB/Swiss-Prot
    Q9UFG4
    UniProtKB/TrEMBL
    A0A024R5Z4
  2. XM_047432873.1XP_047288829.1  protein mono-ADP-ribosyltransferase PARP6 isoform X1

  3. XM_011521805.3XP_011520107.1  protein mono-ADP-ribosyltransferase PARP6 isoform X6

    See identical proteins and their annotated locations for XP_011520107.1

    Conserved Domains (1) summary
    cd01341
    Location:336460
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  4. XM_047432877.1XP_047288833.1  protein mono-ADP-ribosyltransferase PARP6 isoform X5

    Related
    ENSP00000456468.1, ENST00000564610.5
  5. XM_047432876.1XP_047288832.1  protein mono-ADP-ribosyltransferase PARP6 isoform X4

    UniProtKB/TrEMBL
    J7MDH3
    Related
    ENSP00000260376.7, ENST00000260376.11
    Conserved Domains (2) summary
    cd01341
    Location:222358
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    cl00283
    Location:470497
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  6. XM_047432875.1XP_047288831.1  protein mono-ADP-ribosyltransferase PARP6 isoform X3

    UniProtKB/TrEMBL
    H3BRR4
    Related
    ENSP00000456370.1, ENST00000565443.5

RNA

  1. XR_007064475.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    70057855..70089224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020213.1: Suppressed sequence

    Description
    NM_020213.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.